Evidence map›Paper›PMID 40933288›Full record

ArticleBrain communications2025

Impact of anterior callosal disconnection on picture naming in frontal lobe epilepsy surgery.

Davide Giampiccolo, Lawrence P Binding, Umesh Vivekananda, Zara Fenlon, Roman Rodionov, Jane de Tisi, Fenglai Xiao, Aidan O'Keeffe, Andrew W McEvoy, Fahmida A Chowdhury and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Beyond Broca and Wernicke: Epilepsy surgery in the language areas.Epileptic disorders : international epilepsy journal with videotape · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Davide GiampiccoloDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-3849-4168
Lawrence P BindingDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Umesh VivekanandaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0001-6116-2335
Zara FenlonDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Roman RodionovDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Jane de TisiDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Fenglai XiaoDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-1308-6539
Aidan O'KeeffeSchool of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Andrew W McEvoyDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Fahmida A ChowdhuryDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Sallie A BaxendaleDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-9930-6469
Anna MiserocchiDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-1373-0681

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy surgery in focal, drug-resistant frontal lobe epilepsy can be curative and resection is aimed at seizure freedom. The cognitive impact of surgery, however, is less clear-cut. On one hand, resection of the epileptogenic zone can disconnect essential brain networks and therefore cause dysfunction. On the other hand, surgery may prompt recovery of normal brain function by restoring normal electrical activity as propagating epileptic discharges affect cognition outside the epileptogenic zone. To understand the impact of surgery on cognitive outcome, we investigated picture naming in 51 patients undergoing frontal lobe epilepsy surgery (28 left-hemisphere-dominant; 23 language-dominant) preoperatively and at 12 months follow-up using complementary voxel-based lesion symptom mapping, tractwise voxel-based disconnectome and tractography analyses to investigate cortical regions and white matter structures associated with language performance. Naming performance significantly improved 1 year after surgery compared with preoperatively, irrespective of the operated hemisphere or dominance. Improved naming performance was associated with freedom from seizures with impaired awareness. No damage to any region or white matter structure was associated with language decline. Voxel-based disconnectome analysis identified a region in the anterior corpus callosum associated with improved naming. This was confirmed by the tractography disconnectome analysis showing that naming improvement was linked to anterior callosal disconnection between regions linking presupplementary/supplementary motor areas, posterior middle frontal and inferior frontal gyri bilaterally. Our results suggest that seizure reduction can underlie language improvement: in line with results from hemispherotomy or callosotomy, isolating epileptic activity from the language network through callosal disconnection may support cognitive recovery.

Indexed as

disconnectionepilepsyepilepsy surgeryfrontal lobelanguage

Identifiers

PMID40933288
PMCPMC12417999

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.