Evidence map›Paper›PMID 40933286›Full record

ArticleBrain communications2025

Mapping the distribution of neurotransmitters to resting-state functional connectivity in Parkinson's disease.

Weihua Li, Nicholas P Lao-Kaim, Runtian Li, Antonio Martín-Bastida, Andreas-Antonios Roussakis, Graham E Searle, Natalie Valle-Guzman, Viswas Dayal, Dilan Athauda, Zinovia Kefalopoulou and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Weihua LiDivision of Neurology, Department of Brain Science, Imperial College London, London W12 0NN, UK.
Nicholas P Lao-KaimDivision of Neurology, Department of Brain Science, Imperial College London, London W12 0NN, UK.
Runtian LiSchool of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing 100876, China.
Antonio Martín-BastidaDepartment of Neurology and Neurosciences, Clínica Universidad de Navarra, Pamplona-Madrid 31008, Spain.
Andreas-Antonios RoussakisDivision of National Heart & Lung Institute, Department of Vascular Science, Imperial College London, London SW3 6LY, UK.ORCID https://orcid.org/0000-0001-5748-6978
Graham E SearleInvicro, London, W12 0NN, UK.
Natalie Valle-GuzmanDepartment of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.
Viswas DayalDepartment of Clinical and Movement Neurosciences, University College London Institute of Neurology, London WC1N 3BG, UK.
Dilan AthaudaDepartment of Clinical and Movement Neurosciences, University College London Institute of Neurology, London WC1N 3BG, UK.
Zinovia KefalopoulouDepartment of Clinical and Movement Neurosciences, University College London Institute of Neurology, London WC1N 3BG, UK.
Philipp MahlknechtDepartment of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria.ORCID https://orcid.org/0000-0003-0671-0516
Alistair ChurchRoyal Gwent Hospital, Cardiff, NP20 2UB, UK.
Kathryn J PeallNeuroscience and Mental Health Research Institute, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, UK.ORCID https://orcid.org/0000-0003-4749-4944
Håkan WidnerDivision of Neurology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund 22185, Sweden.
Gesine PaulDivision of Neurology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund 22185, Sweden.
Tom FoltynieDepartment of Clinical and Movement Neurosciences, University College London Institute of Neurology, London WC1N 3BG, UK.
Roger A BarkerDepartment of Clinical Neuroscience, University of Cambridge, Cambridge CB2 0SZ, UK.
Paola PicciniDivision of Neurology, Department of Brain Science, Imperial College London, London W12 0NN, UK.ORCID https://orcid.org/0000-0003-4162-6141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine and serotonin are two major monoamine neurotransmitters associated with Parkinson's disease (PD), but their spatial distribution and relationship to underlying functional brain architecture are not fully understood. We assessed 30 patients with PD at baseline using structural MRI, resting-state functional MRI (rs-fMRI),

Indexed as

dopaminefunctional connectivityParkinson’s diseasePET imagingserotonin

Identifiers

PMID40933286
PMCPMC12418387

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.