Evidence map›Paper›PMID 40933283›Full record

ArticleBrain communications2025

Replication of the 2023 radiologically isolated syndrome criteria in a multi-centre cohort.

Friederike Held, Paula Uibel, Cornelius Berberich, Jonas Schaller-Nagengast, Vasil Mitrevski, Leo Hutter, Hayrettin Tumani, Joachim Havla, Christiane Gasperi, Mark Mühlau and 3 more

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In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Friederike HeldTechnical University of Munich, School of Medicine and Health, Department of Neurology, TUM University Hospital, 81675 Munich, Germany.
Paula UibelTechnical University of Munich, School of Medicine and Health, Department of Neurology, TUM University Hospital, 81675 Munich, Germany.
Cornelius BerberichTechnical University of Munich, School of Medicine and Health, Department of Neuroradiology, TUM University Hospital, 81675 Munich, Germany.
Jonas Schaller-NagengastDepartment of Neurology, University Hospital Ulm, 89081 Ulm, Germany.
Vasil MitrevskiLudwig-Maximilians-University, Institute of Clinical Neuroimmunology, LMU Hospital, 81377 Munich, Germany.
Leo HutterLudwig-Maximilians-University, Institute of Clinical Neuroimmunology, LMU Hospital, 81377 Munich, Germany.
Hayrettin TumaniDepartment of Neurology, University Hospital Ulm, 89081 Ulm, Germany.
Joachim HavlaLudwig-Maximilians-University, Institute of Clinical Neuroimmunology, LMU Hospital, 81377 Munich, Germany.
Christiane GasperiTechnical University of Munich, School of Medicine and Health, Department of Neurology, TUM University Hospital, 81675 Munich, Germany.
Mark MühlauTechnical University of Munich, School of Medicine and Health, Department of Neurology, TUM University Hospital, 81675 Munich, Germany.ORCID https://orcid.org/0000-0002-9545-2709
Achim BertheleTechnical University of Munich, School of Medicine and Health, Department of Neurology, TUM University Hospital, 81675 Munich, Germany.
Jan S KirschkeTechnical University of Munich, School of Medicine and Health, Department of Neuroradiology, TUM University Hospital, 81675 Munich, Germany.
Bernhard HemmerTechnical University of Munich, School of Medicine and Health, Department of Neurology, TUM University Hospital, 81675 Munich, Germany.ORCID https://orcid.org/0000-0001-5985-6784

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiologically isolated syndrome (RIS) represents a pivotal stage for identifying individuals at high risk of transitioning into multiple sclerosis (MS). Early therapy initiation reduces the risk of conversion. The 2023-RIS criteria were proposed to identify presymptomatic individuals earlier. We aimed to replicate the diagnostic value of the 2023-RIS criteria in an independent cohort. In this retrospective cohort study, individuals diagnosed with RIS and longitudinally followed in three centres were stratified by the 2009- and 2023-RIS criteria. We conducted comparative analyses, including survival, hazard ratio and performance evaluations. Among

Indexed as

conversiondiagnostic criteriamultiple sclerosisradiologically isolated syndromerisk factor

Identifiers

PMID40933283
PMCPMC12417997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.