Evidence map›Paper›PMID 40933229›Full record

ReviewJournal of orthopaedic translation2025

Immunoporosis: The hidden link between aging immune cells and bone fragility.

Xinyi Cheng, Yida Chen, Xichao Zhou, Qiaoli Gu, Huan Zhao, Chao Wan, Mimi Chen, Huilin Yang, Qin Shi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic translation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The role of CD8Frontiers in immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinyi ChengDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, China.
Yida ChenDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, China.
Xichao ZhouDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, China.
Qiaoli GuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, China.
Huan ZhaoDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, China.
Chao WanKey Laboratory of Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Mimi ChenDepartment of Orthopedics, Children Hospital of Soochow University, No.92 Zhongnan Street, Suzhou, 215000, Jiangsu, China.
Huilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, China.
Qin ShiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis (OP) is a serious public health problem affecting the elderly worldwide. The immune system is well-known to play an important role in bone metabolism and formation. However, immunosenescence, defined as the gradual deterioration of immune system function with aging, has become one of the key factors that drive OP, referred to as immunoporosis. Immune cells may experience substantial functional and phenotypic alterations with aging, disturbing the intricate balance between bone formation and resorption, ultimately leading to bone loss and fragility. These alterations promote osteoclastogenesis and impair osteogenesis through the release of senescence-associated secretory phenotype (SASP) factors and other signaling pathways, a phenomenon referred to as "inflammaging". Accordingly, the present review summarizes the latest findings on the interplay between immunosenescence and bone biology, with a purpose to shed light on the molecular and cellular processes that drive the development of OP. This study is anticipated to provide potential reference for developing innovative therapeutic strategies targeting immunosenescence to rescue bone fragility and enhance skeletal health in older adults. The Translational potential statement: This review highlights the role of immunosenescence in the development of OP and suggests it as a possible treatment target. We summarize the mechanisms of senescent immune cells affecting bone metabolism balance and removing these cells or blocking their secretions [e.g., SASPs] in reducing bone loss. Several preclinical studies have shown that drugs targeting immunosenescence can improve bone health in animal models. Recent clinical studies also report links between immunosenescence markers (e.g., CD4

Indexed as

Aging immune cellsBone metabolismImmunosenescenceOsteoimmunologyOsteoporosis

Identifiers

PMID40933229
PMCPMC12417214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.