Evidence map›Paper›PMID 40933224›Full record

ArticleLe infezioni in medicina2025

Validation of a clinical scoring system to differentiate mycobacterial and bacterial causes of spondylodiscitis: a retrospective cohort study from Kerala, India.

Vettakkara Kandy Muhammed Niyas, Rajalakshmi Ananthanarayanan, Mohamed Puthiyaveettil Zunimol, Dheeraj Mohan, Sundeep Malla, Steven Van Den Broucke, Erika Vlieghe, Emmanuel Bottieau, Nitin Gupta

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Article in Le infezioni in medicina, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Vettakkara Kandy Muhammed NiyasDepartment of Infectious Diseases, KIMSHEALTH, Thiruvananthapuram, Kerala, India.
Rajalakshmi AnanthanarayananDepartment of Infectious Diseases, KIMSHEALTH, Thiruvananthapuram, Kerala, India.
Mohamed Puthiyaveettil ZunimolDepartment of Radiology, KIMSHEALTH, Thiruvananthapuram, Kerala, India.
Dheeraj MohanDepartment of Family Medicine, KIMSHEALTH, Thiruvananthapuram, Kerala, India.
Sundeep MallaDepartment of Radiodiagnosis, Amrita Institute of Medical Sciences, Faridabad, India.
Steven Van Den BrouckeDepartment of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Erika VliegheDepartment of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Emmanuel BottieauDepartment of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Nitin GuptaDepartment of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mycobacterial and bacterial spondylodiscitis require distinct therapeutic approaches. However, microbiological diagnosis is often delayed or unavailable in resource-limited settings. This study aimed to validate a clinical scoring system developed in a prior retrospective cohort study in Karnataka (India) to differentiate these aetiologies. Methods: We conducted a retrospective cohort study of patients with microbiologically confirmed spondylodiscitis admitted between January 2017 and August 2024 in a tertiary care centre in Kerala, India. Demographic, clinical, laboratory, imaging, and treatment data were compared between the two groups, and the scoring system's diagnostic performance was assessed. Results: Of 151 patients with infectious spondylodiscitis, 73 patients with community-acquired microbiologically confirmed infection were included. Of these, 32 (44%) had mycobacterial, and 41 (56%) had bacterial spondylodiscitis [ Conclusions: The validated clinical scoring system reliably distinguishes mycobacterial from bacterial spondylodiscitis and may guide empirical management in settings where timely microbiological diagnosis is not feasible.

Indexed as

bacterial infectionclinical scoring systemmycobacterial infectionspondylodiscitis

Identifiers

PMID40933224
PMCPMC12419165

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