Evidence map›Paper›PMID 40933141›Full record

ArticleACS ES&T water2025

Discovery of Novel Hydroxyproline-Containing Microcystins in Western Lake Erie Cyanobacterial Bloom Samples.

Sanduni H Premathilaka, Judy A Westrick, Dragan Isailovic

Abstract read
In one paragraph

Article in ACS ES&T water, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sanduni H PremathilakaDepartment of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.
Judy A WestrickDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.ORCID 0000-0002-1712-5737
Dragan IsailovicDepartment of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.ORCID 0000-0002-1094-7738

Funding

The synergistic effects of climate and anthropogenic drivers on toxic cyanobacterial bloomsP01ES028939 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gregory James Dick, David Joseph Kennedy · 2018 to 2026
$3.7M
Synthesis and quantitation of microcystins and anabaenopeptins in the Great Lakes region to establish human exposure risks via ingestion and inhalationR01ES034017 · NIEHS · WAYNE STATE UNIVERSITY · PI Andrew P Ault, Andrew Michael Fribley · 2023 to 2026
$2.3M
Discovery of Novel Cyanotoxins by Detection of Their Native Fluorescence and Unique MS/MS Fragments, and Determination of Their ToxicitiesR15ES036709 · NIEHS · UNIVERSITY OF TOLEDO · PI ISAILOVIC, DRAGAN · 2024 to 2024
$459k
NIEHS NIH HHS P01 ES028939NIEHS NIH HHS R01 ES034017NIEHS NIH HHS R15 ES036709
6 · The paper itself

Abstract

From midsummer to fall, cyanobacterial harmful algal blooms (cHABs) producing microcystins (MCs), a class of hepatotoxic cyclic heptapeptides, plague Lake Erie's western basin. Since MC congener toxicities vary over 2 orders of magnitude, identification and characterization of the microcystin congener profile can be crucial information when balancing between public health and local economic resilience. Herein, five hydroxyproline (Hyp)-containing MCs were discovered in a Lake Erie cHAB. High-resolution liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS), tandem mass spectrometry (MS/MS), and thiol derivatization were used in the putative identification of novel MC congeners. Among the five novel congeners, MC-LHyp, MC-HpeHyp, [Dhb

Indexed as

high-resolution tandem mass spectrometryhydroxyprolinemicrocystinsstructure elucidation

Identifiers

PMID40933141
PMCPMC12419242

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.