ReviewJournal of the Society for Cardiovascular Angiography & Interventions2025
Aortic Valve Replacement in Asymptomatic Severe Aortic Stenosis: A Systematic Review and Meta-Analysis.
Review in Journal of the Society for Cardiovascular Angiography & Interventions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Aortic Valve Replacement for Asymptomatic Severe Aortic Stenosis: A New Management Paradigm?Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Current guidelines recommend a strategy of clinical surveillance (CS) for patients with asymptomatic severe aortic stenosis and normal left ventricular ejection fraction. Methods: PubMed, Embase, and ClinicalTrials.gov were searched through November 2024 for randomized controlled trials (RCTs) and observational studies comparing surgical aortic valve replacement or transcatheter aortic valve replacement with CS in patients with asymptomatic severe aortic stenosis. Results: Sixteen eligible studies (12 observational studies and 4 RCTs) were identified, with a total of 3919 patients in the observational studies and 1427 patients in the RCTs. In the pooled analyses combining observational studies and RCTs, aortic valve replacement (AVR) was associated with significantly reduced all-cause mortality (incidence rate ratio [IRR], 0.42; 95% CI, 0.31-0.58; Conclusions: Data from observational studies and recent RCTs suggest that a strategy of preemptive AVR is associated with improved survival and lower rates of unplanned cardiovascular or HF-related hospitalizations and stroke compared to CS.
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Registered trials
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