SynthesisFrontiers in neurology2025
The effects of nine types of exercise rehabilitation therapies on improving limb balance, cognitive and emotional function, and quality of life in elderly patients with Parkinson's disease: a network meta-analysis of 55 RCTs.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Potential Mechanisms of Exercise-Mediated Ferroptosis Regulation in Central Nervous System Diseases.Molecular neurobiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Parkinson's disease (PD) is a common neurodegenerative disorder that primarily affects individuals over the age of 60. Impaired limb balance, cognitive decline, and emotional disturbances are core symptoms of PD, significantly impacting patients' quality of life. While medication can alleviate motor symptoms, its effectiveness in improving non-motor symptoms (such as cognitive and emotional disturbances) is limited, and long-term use may lead to adverse effects. In recent years, exercise therapy has garnered increasing attention due to its safety, accessibility, and potential to offer both motor and non-motor benefits, making it an important direction in PD rehabilitation research. This study systematically evaluated nine exercise rehabilitation interventions to provide evidence-based non-pharmacological alternatives for PD management. Methods: A systematic search of six major databases was conducted, and 55 randomized controlled trials involving 4,417 patients with Parkinson's disease were included. The outcome measures were evaluations of balance, cognition, Emotional Functions, and quality of life-related indicators. Stata 17.0 was used to perform a net meta-analysis to assess the relative effectiveness of each intervention and to test the consistency of direct and indirect evidence. Results: Exoskeletal Training (ET) was the most effective intervention for improving balance (SMD = -2.52, 95% CI [-3.38, -1.67], Conclusion: Dance (DA) is the most effective intervention for improving balance, while aquatic training (ABT) and resistance training (RT) are most effective for emotional regulation. Mind-body exercise (MBE) demonstrates exceptional efficacy in cognitive function, while resistance training has the greatest impact on improving quality of life. These findings provide evidence-based guidance for optimizing exercise-based rehabilitation for Parkinson's disease, supporting tailored interventions targeting specific symptom domains. Future research should focus on refining protocols to maximize treatment efficacy.
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Registered trials
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