ArticleFrontiers in neurology2025
CPAP modulation of sleep microstructure (N2-SSD and REM-AHI) as predictors of neurological recovery in ischemic stroke patients with moderate-to-severe OSA.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
Background: There is a disease spectrum of ischemic stroke (IS) and obstructive sleep apnea (OSA), which are often comorbid in the same patient and consequently increases prognostic risk. Continuous positive airway pressure (CPAP) therapy is the primary treatment for stroke-related OSA; however, its positive effects on patient prognosis and the underlying mechanisms remain controversial. Objective: This study aimed to investigate the impact of CPAP therapy on the recovery of IS patients with moderate-to-severe OSA and to identify biomarkers significantly associated with prognosis to assess their predictive value for short-term neurological outcomes. The findings are expected to optimize treatment strategies and improve overall patient outcomes. Methods: A total of 141 patients with IS combined with moderate-to-severe OSA admitted to the Affiliated Hospital of Yangzhou University from October 2022 to August 2024 were enrolled. Patients were divided into a CPAP group ( Results: Compared with those in the control group, patients in the CPAP group had lower modified Rankin scale (mRS) and National Institutes of Health Stroke Scale (NIHSS) scores after treatment ( Conclusion: CPAP therapy enhances sleep microstructure and oxygenation parameters, which improves sleep quality. N2-SSD, REM-AHI, and Mean SpO
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