Evidence map›Paper›PMID 40933043›Full record

ArticleFrontiers in neurology2025

Modified-mindfulness-based stress reduction as a treatment for cognitive recovery in patients with minor stroke: a randomized controlled pilot study.

Sophia G Girgenti, Isabella Dallasta, Erin Lawrence, Dawn Merbach, Jonathan Z Simon, Rafael H Llinas, Neda F Gould, Elisabeth Breese Marsh

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04302493 (Mindfulness Matters), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04302493 nacompletednot on this map

Mindfulness Matters: The Impact of Mindfulness Based Stress Reduction on Post-Stroke Cognition

TypeinterventionalSponsorJohns Hopkins UniversityRan2021 to 2023Enrolled30ConditionsStroke, Stroke Sequelae, Depression, Cognitive ImpairmentArmsMindfulness Based Stress Reduction (MBSR), Stroke Support Group (SSG)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Functional Connectivity Linked to Cognitive Recovery After Minor Stroke.Annals of clinical and translational neurology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sophia G GirgentiDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Isabella DallastaDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Erin LawrenceDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Dawn MerbachDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Jonathan Z SimonDepartment of Electrical Engineering, University of Maryland, College Park, MD, United States.
Rafael H LlinasDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Neda F GouldDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Elisabeth Breese MarshDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States.

Funding

Mindfulness Matters: TheImpact of Mindfulness Based Stress Reduction on Post-Stroke CognitionR21AG068802 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARSH, ELISABETH BREESE · 2020 to 2020
$460k
NIA NIH HHS R21 AG068802
6 · The paper itself

Abstract

Background: Well-developed rehabilitation paradigms exist for post-stroke language and motor impairments. However, no such recovery program has been identified for commonly disabling cognitive deficits in patients following minor stroke. Mindfulness Based Stress Reduction (MBSR) is thought to engage the frontal lobes, improving concentration and attention, and therefore may be an effective option. Methods: We prospectively enrolled a cohort of patients with subacute minor stroke and randomized them to either an 8-week online modified-MBSR course or online traditional Stroke Support Group (SSG). All patients underwent a battery of cognitive tests and measures of patient reported outcomes (PROs) pre- and post-intervention. ANOVA was used to compare changes in scores over time across both groups, along with a third group of control patients having received neither intervention ( Results: A total of 30 patients were randomized ( Conclusion: m-MBSR may modestly improve frontal lobe activity and demonstrates some success in increasing cognitive performance. However, further studies are needed to determine if it is more efficacious in the chronic stage of recovery when more patients are able to fully engage and actively participate.

Indexed as

cognitioncognitive networksmindfulnessrecoverystroke

Identifiers

PMID40933043
PMCPMC12418779

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.