ArticleCureus2025
miR-872 Protection Against Renal Ischemia-Reperfusion Injury via Targeting HMOX1.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Renal ischemia-reperfusion (IR) is an inevitable process in kidney transplantation and a main cause of acute kidney injury (AKI). The present study aimed to explore the potential miRNA-mRNA network in the development of renal IR injury (RIRI). Methods and results The rat IR model and cell hypoxia/reoxygenation (H/R) model were established. AKI was confirmed in Wistar rats through renal histology evaluation and blood urea nitrogen (BUN) levels. We observed a significant decrease in miR-872 in both in vivo and in vitro models. Through function assays, we confirmed the detrimental effect of miR-872 downregulation and identified HMOX1 as its direct downstream target. Using miR-872 angomir, cell apoptosis was significantly impeded. Conclusions The present study demonstrated that miR-872 mitigated IR injury by downregulating HMOX1, providing new avenues to treat RIRI by manipulating miRNA levels.
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