ReviewCureus2025
Oral Manifestations in Children With Neutropenia: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutropenia is a hematological disorder marked by low neutrophil counts, predisposing affected children to severe infections, including those in the oral cavity. Early identification of oral signs may facilitate timely hematological referral and intervention. This systematic review investigated oral manifestations in neutropenic children and emphasized the diagnostic role of pediatric dentists. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, five databases (PubMed, Scopus, EMBASE, Web of Science, and Ovid Medline) were searched up to April 2025, yielding 22 studies, including 19 case reports and three cross-sectional studies. The most frequently reported oral findings were chronic gingivitis, periodontitis, ulcers, and horizontal bone loss. Clinical presentation and severity varied among neutropenia subtypes. Due to heterogeneity, prevalence estimates were limited; however, one cross-sectional study reported gingival bleeding in 73.3% and mouth sores in 53.3% of neutropenic children. The review concluded that oral signs may serve as early indicators of neutropenia, but the current evidence is constrained by selection bias and inconsistent reporting. Pediatric dentists should interpret these manifestations as suggestive rather than diagnostic. Future studies should aim for standardized reporting and subtype-specific analysis to enhance the clinical value of oral indicators in neutropenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.