ArticleCureus2025
Diffuse Alveolar Hemorrhage Leading to Respiratory Failure in Mixed Phenotype Acute Leukemia: A Fatal Pulmonary Complication.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Mixed phenotype acute leukemia (MPAL) is a rare and diagnostically challenging hematologic malignancy characterized by the co-expression of myeloid and lymphoid lineage markers. We present the case of a 61-year-old woman with newly diagnosed MPAL who developed diffuse alveolar hemorrhage (DAH) shortly after induction chemotherapy. Despite aggressive supportive care, including bronchoscopy-guided diagnosis, high-dose corticosteroids, antifibrinolytics, and lung-protective ventilation with prone positioning, her condition rapidly deteriorated into multi-organ failure and death. This case highlights the need for early recognition of pulmonary complications in high-risk leukemias and underscores the limitations of current management strategies in the setting of DAH complicating MPAL.
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