Evidence map›Paper›PMID 40932680›Full record

ArticleAging2025

Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos.

Myriam Fornage, Wassim Tarraf, Rui Xia, Adriana Ordonez, Tamar Sofer, Freddie Márquez, Bharat Thyagarajan, Gregory A Talavera, Linda C Gallo, Charles DeCarli and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Myriam FornageInstitute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Wassim TarrafInstitute of Gerontology and Department of Healthcare Sciences, Wayne State University, Detroit, MI 48202, USA.
Rui XiaInstitute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Adriana OrdonezInstitute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Tamar SoferDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Freddie MárquezDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Gregory A TalaveraDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Linda C GalloDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Charles DeCarliDepartment of Neurology, University of California, Sacramento, CA 95817, USA.
Hector M GonzálezDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.

Funding

Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseR01AG075758 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Charles DeCarli, Hector M Gonzalez · 2022 to 2026
$21.7M
Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse LatinosRF1AG061022 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FORNAGE, MYRIAM, GONZALEZ, HECTOR M · 2019 to 2019
$6.6M
Early and life course socioeconomic adversity and dementia risk in Hispanics/LatinosRF1AG077639 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2022 to 2023
$1.9M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIA NIH HHS R01 AG075758NIA NIH HHS RF1 AG061022NIA NIH HHS RF1 AG077639
6 · The paper itself

Abstract

Due to the paucity of longitudinal DNA methylation data (DNAm), especially among Hispanic/Latino adults, the association between changes in epigenetic clocks over time and cognitive aging phenotypes has not been investigated. This longitudinal study included 2671 Hispanic/Latino adults (57 years; 66% women) with blood DNAm data and neurocognitive function assessed at two visits ~7 years apart. We evaluated the associations of 5 epigenetic clocks and their between-visit change with multiple measures of cognitive aging that included a global and domain-specific cognitive function score at each visit, between-visit change in global and domain-specific cognitive function score, and MCI diagnosis at visit 2 (V2). There were significant associations between greater acceleration of all clocks and lower cognitive function at each visit and MCI at V2. The strongest associations were observed for GrimAge and DunedinPACE. There were significant associations of between-visit increase in PhenoAge and GrimAge acceleration with decline in cognitive function and greater risk of MCI diagnosis at V2. Epigenetic aging is associated with lower global and domain-specific cognitive function, greater cognitive decline, and greater risk of MCI in Hispanic/Latino adults. Longitudinal assessment of change in age acceleration for second-generation clocks, GrimAge and PhenoAge may provide additional value in predicting cognitive aging beyond a single time point assessment.

Indexed as

AgingCognitive AgingCognitive DysfunctionEpigenesis, GeneticHispanic or LatinoAgedCognitionDNA MethylationFemaleHumansLongitudinal StudiesMaleMiddle AgedWhitecognitive functiondementiaDNA methylationepigenetic clocksHispanic/Latinos

Identifiers

PMID40932680
PMCPMC12606969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.