Evidence map›Paper›PMID 40932662›Full record

ArticlePflugers Archiv : European journal of physiology2025

Effects of intrarenal afferent stimulation by bradykinin on renal sympathetic nerve activity: tonic inhibition contributing to renal function.

Eva Hutter, Tilmann Ditting, Martin Hindermann, Karl F Hilgers, Roland E Schmieder, Christian Morath, Mario Schiffer, Kerstin Amann, Roland Veelken, Kristina Rodionova

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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eva HutterDepartment of Internal Medicine 4 - Nephrology and Hypertension, Friedrich-Alexander University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Tilmann DittingDepartment of Internal Medicine 4 - Nephrology and Hypertension, Friedrich-Alexander University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Martin HindermannDepartment of Internal Medicine 4 - Nephrology and Hypertension, Friedrich-Alexander University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Karl F Hilgers
Roland E SchmiederDepartment of Internal Medicine 4 - Nephrology and Hypertension, Friedrich-Alexander University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Christian MorathDepartment of Internal Medicine 4 - Nephrology and Hypertension, Paracelsus Medical University Nuremberg, Nuremberg, Germany.
Mario SchifferDepartment of Internal Medicine 4 - Nephrology and Hypertension, Friedrich-Alexander University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Kerstin AmannDepartment of Pathology, Friedrich-Alexander University Erlangen, Erlangen, Germany.
Roland VeelkenDepartment of Internal Medicine 4 - Nephrology and Hypertension, Friedrich-Alexander University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany. roland.veelken@uk-erlangen.de.
Kristina RodionovaDepartment of Internal Medicine 4 - Nephrology and Hypertension, Friedrich-Alexander University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.

Funding

Deutsche Forschungsgemeinschaft 248553778
6 · The paper itself

Abstract

Bradykinin (BK) may increase renal sodium excretion by decreasing tubular ENaC activity. Afferent renal nerve activity (ARNA) putatively controls renal sympathetic nerve activity (RSNA) involved in renal sodium handling. We recently found tonic sympatho-inhibition due to intrarenal ARNA stimulation by the TRPV1 agonist capsaicin (CAP). Since BK is known to augment TRPV1 effects, we hypothesized that intrarenally applied BK also tonically inhibits RSNA. Four groups of rats (n = 8; BK, CAP, HOE + BK, NaCl-control) were equipped with arterial and venous catheters for blood pressure (BP) and heart rate (HR) recordings and drug application; bipolar electrodes for RSNA and ARNA recordings, renal arterial catheter for intrarenal administration (IRA) of bradykinin (BK: 10

Indexed as

BradykininKidneySympathetic Nervous SystemAnimalsBlood PressureBradykinin B2 Receptor AntagonistsCapsaicinHeart RateMaleRatsRats, Sprague-DawleyRats, WistarTRPV Cation ChannelsBradykininBradykinin B2 Receptor AntagonistsCapsaicinicatibantTrpv1 protein, ratTRPV Cation ChannelsB2 receptorsBradykininRenal functionRenal innervationSympathoinhibitionTRPV1

Identifiers

PMID40932662
PMCPMC12640332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.