Evidence map›Paper›PMID 40932642›Full record

ReviewJournal of neurology2025

Correlation between metabolism and neuroinflammation of astrocytes in drug-resistant epilepsy.

Xiao-Xiao Yu, Da Xu, Shuang Chen, Qiang Liu, Hai-Jun Wang, Man Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Immune dysregulation and epileptogenesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiao-Xiao Yu *Department of Neurology, Union Hospital, Tongji Medical College,, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei, China.
Da Xu *Department of Neurology, Union Hospital, Tongji Medical College,, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei, China.
Shuang Chen *Department of Neurology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
Qiang LiuDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei, China.
Hai-Jun WangDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei, China. whj11260@163.com.
Man LiDepartment of Neurology, Union Hospital, Tongji Medical College,, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei, China. mmllsy@126.com.ORCID http://orcid.org/0000-0002-7319-4235

Funding

National Natural Science Foundation of China 82171315
6 · The paper itself

Abstract

Epilepsy is a chronic neurological disorder. Although anti-seizure medications (ASMs) are currently primary treatment for epilepsy, about one-third of patients develop drug resistant epilepsy (DRE). Relevant studies have found that astrocytes are not only involved in regulating the metabolism of neuronal networks, but are also closely associated with the development of neuroinflammation, both of which are related to the development of DRE. Therefore, we performed a deep exploration of the relationship between astrocytes abnormal metabolism and neuroinflammation, hoping to provide new insights into therapeutic approaches for DRE.

Indexed as

AstrocytesDrug Resistant EpilepsyNeuroinflammatory DiseasesAnimalsHumansAstrocytesDrug-resistant epilepsyMetabolismNeuroinflammation

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.