Evidence map›Paper›PMID 40932640›Full record

ArticleJournal of neuro-oncology2025

Stereotactic radiosurgery for lung cancer spinal metastases.

Michael R Kann, Samuel Adida, Suchet Taori, Shovan Bhatia, Akshath Rajan, James C Bayley, Pascal O Zinn, Steven A Burton, John C Flickinger, Roberta K Sefcik and 1 more

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Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael R KannUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Samuel AdidaUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Suchet TaoriUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Shovan BhatiaUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Akshath RajanDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
James C BayleyDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Pascal O ZinnDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Steven A BurtonDepartment of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
John C FlickingerDepartment of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Roberta K SefcikDepartment of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA.
Peter C GersztenDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. gerspc@upmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLung cancer spinal metastases may present with intractable pain and neurological deficits. This study is one of the largest to examine outcomes following stereotactic radiosurgery (SRS) in this patient population.

methodsA single institution retrospectively collected database of patients with lung cancer spinal metastases treated with SRS between 2003-2023 was analyzed. The primary outcome was local control (LC). Secondary outcomes included pain response, overall survival (OS), and radiation-induced toxicity. The median single-fraction dose was 16 Gy (range: 12-20). Multi-fractionated treatments utilized doses of 18-30 Gy in 2-5 fractions.

resultsOne hundred twenty-two patients with 167 lesions met inclusion criteria. Prior to radiosurgery, 21 lesions (13%) underwent open resection and 131 lesions (78%) received external beam radiation therapy. Median follow-up was 4 months (range: 1-133). Fifteen lesions (9%) locally recurred 5 months (range: 1-10) after treatment. Six-month and 1-year LC rates were 88% and 75%, respectively. Patient-reported pain predominantly improved or remained stable (67%) after treatment; worsened pain was associated with inferior LC (p < 0.01, HR: 22.7, 95% CI: 2.5-207.1) and development of radiation-induced vertebral compression fractures (VCFs) (p < 0.01, OR: 34.2, 95% CI: 3.0-392.4). Six-month and 1-year OS rates were 45% and 23%, respectively. Low functional status (Karnofsky Performance Score ≤ 70) was associated with inferior LC (p = 0.03, HR: 3.7, 95% CI: 1.1-12.1) and OS (p = 0.03, HR: 1.8, 95% CI: 1.1-2.9). Thirty-one radiation-induced toxicities (19%), including 13 VCFs (8%), were observed.

conclusionsRadiosurgery provides LC and pain palliation with minimal rates of toxicity in a challenging patient population with lung cancer spinal metastases.

Indexed as

Lung NeoplasmsRadiosurgerySpinal NeoplasmsAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeLocal tumor controlLung metastasisSBRTSpine stereotactic radiosurgerySRSStereotactic radiosurgery

Identifiers

PMID40932640

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.