Evidence map›Paper›PMID 40932625›Full record

ArticleThe Journal of experimental medicine2025

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation.

Jinjin Xu, Lingjia Kong, Elizabeth A Creasey, Sneha Rath, Lei Deng, Julian Avila-Pacheco, Chenhao Li, Blayne A Oliver, Tyler T Dao, Angela R Shih and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jinjin XuCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.ORCID 0000-0003-0041-6287
Lingjia KongCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.ORCID 0000-0003-1016-030X
Elizabeth A CreaseyCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.ORCID 0000-0002-9724-7979
Sneha RathDepartment of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8839-1285
Lei DengCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.ORCID 0000-0003-0391-6180
Julian Avila-PachecoBroad Institute of MIT and Harvard , Cambridge, MA, USA.ORCID 0000-0001-9388-3946
Chenhao LiCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.ORCID 0000-0003-1182-6804
Blayne A OliverCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.ORCID 0000-0001-8185-0215
Tyler T DaoBroad Institute of MIT and Harvard , Cambridge, MA, USA.ORCID 0000-0003-1468-3896
Angela R ShihDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8945-5997
Mark J DalyBroad Institute of MIT and Harvard , Cambridge, MA, USA.ORCID 0000-0002-0949-8752
Alex K ShalekBroad Institute of MIT and Harvard , Cambridge, MA, USA.ORCID 0000-0001-5670-8778
Clary B ClishBroad Institute of MIT and Harvard , Cambridge, MA, USA.ORCID 0000-0001-8259-9245
Daniel B GrahamCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.ORCID 0000-0002-8403-8115
Jacques DeguineBroad Institute of MIT and Harvard , Cambridge, MA, USA.ORCID 0000-0001-9218-3040
Ramnik J XavierCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.ORCID 0000-0002-5630-5167

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologiesRC2DK135492 · NIDDK · BROAD INSTITUTE, INC. · PI Caroline Uhler, Ramnik J Xavier · 2023 to 2026
$7.9M
Common Fund Data Ecosystem 3OT2OD030544Metabolomics Consortium Coordinating Center 1U2C-DK119889National Metabolomics Data Repository U2C-DK119886NIDDK NIH HHS P30 DK043351NIDDK NIH HHS RC2 DK135492NIH HHS DK043351NIH HHS DK135492The Leona M. and Harry B. Helmsley Charitable Trust
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have linked the locus encoding ankyrin repeat domain 55 (ANKRD55) with numerous autoimmune diseases; however, its biological function and role in inflammation are unclear. Here, we demonstrate that Ankrd55-deficient mice are protected from T cell-mediated colitis but are more susceptible to Citrobacter rodentium infection. Mechanistically, Ankrd55 deletion impairs CD4+ T cell proliferation and reduces effector cytokine production in T helper 17 (TH17) cells in a cell-intrinsic manner. ANKRD55 is associated with mitochondria, and its loss is associated with impaired mitochondrial respiration and activation of the LKB1 pathway. Consistently, IL-17 production can be rescued by the deletion of LKB1 in Ankrd55-deficient T cells. Altogether, our study implicates the protein ANKRD55 as a functional modulator of T cell metabolism that directly impacts TH17 responses, highlighting it as a potential target across multiple autoimmune diseases.

Indexed as

Autoimmune DiseasesTh17 CellsAnimalsCell ProliferationCitrobacter rodentiumColitisEnterobacteriaceae InfectionsGenetic Predisposition to DiseaseInterleukin-17MiceMice, Inbred C57BLMice, KnockoutMitochondriaInterleukin-17

Identifiers

PMID40932625
PMCPMC12869789

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.