ReviewCurrent neurology and neuroscience reports2025
Exercise and Cognition in Multiple Sclerosis in 2025: Forward Momentum or Going Nowhere Fast?
Review in Current neurology and neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
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Abstract
purpose of reviewThere is increasing interest in the study of exercise training as an approach to treat the cognitive consequences of multiple sclerosis (MS). The current paper reviews recent research on exercise training effects on cognition in MS, and provides several future directions for guiding, and perhaps optimizing, research in this area. RECENT
findingsOverall, the newest evidence in this field is associated with substantial heterogeneity in study characteristics (i.e., sample sizes, demographic/clinical characteristics, exercise interventions, control/comparator conditions). The studies further focused on different primary outcomes, such that cognition is inconsistently included as a primary outcome. As a result, the study results were heterogeneous overall. Collectively, evidence on exercise training as an approach to improve cognition in persons with MS over the past two decades is mixed, and the efficacy or effectiveness of such an approach has not yet been established. Based on recently published studies, we believe that future research will involve stronger, better-designed RCTs that evaluate exercise, as a standalone and/or combinatory approach for improving cognition in MS, that are founded upon hypothesized mechanisms-of-action regarding adaptations in the central nervous system.
Indexed as
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40932601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.