Evidence map›Paper›PMID 40932582›Full record

ArticleParasitology research2025

Comparison of the efficacy of local thermotherapy versus Glucantime® in the treatment of anthroponotic cutaneous leishmaniasis: a pilot study.

Fereshteh Safiabadi, Amirali Reihani, Ania Goli Khajeh, Masoud Maleki, Seyyedeh Zahra Ghasemi, Ali Khamesipour, Abdolmajid Fata, Habibollah Esmaily, Vahid Mashayekhi Goyonlo

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fereshteh SafiabadiDepartment of Dermatology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Amirali ReihaniStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Ania Goli KhajehDepartment of Dermatology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Masoud MalekiDepartment of Dermatology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyyedeh Zahra GhasemiCutaneous Leishmaniasis Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Ali KhamesipourCenter for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Abdolmajid FataCutaneous Leishmaniasis Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Habibollah EsmailyDepartment of Statistics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Vahid Mashayekhi GoyonloDepartment of Dermatology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. MashayekhiV@mums.ac.ir.

Funding

Mashhad University of Medical Sciences 930460
6 · The paper itself

Abstract

This pilot study is the first in Iran that evaluates the effectiveness of thermotherapy compared to intralesional Glucantime® in the treatment of cutaneous leishmaniasis caused by Leishmania tropica. Forty patients with cutaneous leishmaniasis were separated into two groups, each consisting of 20 patients. The control group received intralesional Glucantime® weekly for 8 weeks, while the other group received a single session of thermotherapy for each lesion using ThermoMedTM model 1.8. The patients were monitored for 6 months, during which the outcomes were evaluated by considering the dimensions, consistency, and rates of remission of the lesions. The terms "initial remission" and "complete remission" were clearly defined, and any instances of therapy failure were documented. The statistical analysis was conducted using SPSS 24.0, employing independent t-tests, chi-square tests, and ANOVA. Both treatment groups exhibited considerable decreases in lesion size and enhanced texture, with no statistically significant differences. Nevertheless, the group that underwent thermotherapy demonstrated a more significant decrease in lesion size and improvement in texture after 6 months. The remission rates were similar; however, Glucantime® achieved a faster remission. No significant side effects were recorded in either group. The present study showed that thermotherapy was equally effective as intralesional Glucantime® in treating anthroponotic leishmaniasis. Thermotherapy can be considered as an alternative, especially when Glucantime® cannot be used, even though it requires further research.

Indexed as

Antiprotozoal AgentsHyperthermia, InducedLeishmaniasis, CutaneousMeglumineOrganometallic CompoundsAdolescentAdultFemaleHumansIranLeishmania tropicaMaleMeglumine AntimoniateMiddle AgedPilot ProjectsTreatment OutcomeAntiprotozoal AgentsMeglumineMeglumine AntimoniateOrganometallic CompoundsAnthroponotic cutaneous leishmaniasisGlucantime®Leishmania tropicaThermotherapy

Identifiers

PMID40932582
PMCPMC12426069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.