Evidence map›Paper›PMID 40932545›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2026

Baicalin: bridging traditional medicine and modern science in food and functional applications.

Chen-Qin Xu, Yi-Lang Zhong, Tao Liu, Xiao-Hui Yang, Miao-Miao Wang, Chuang Ke, Yong-Bing Cao, Jian Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Modulation of the gut microbiota by traditional Chinese medicine to attenuate chemotherapy-induced toxicity in gastric cancer: a review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chen-Qin XuInstitute of Vascular Anomalies, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China.
Yi-Lang ZhongInstitute of Vascular Anomalies, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China.
Tao LiuDepartment of Hepatobiliary Surgery, Shandong Provincial Hospital Heze Branch, Heze, China.
Xiao-Hui YangInstitute of Vascular Anomalies, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China.
Miao-Miao WangInstitute of Vascular Anomalies, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China.
Chuang KeThe MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Yong-Bing CaoInstitute of Vascular Anomalies, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China. ybcao@vip.sina.com.
Jian ChenInstitute of Vascular Anomalies, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China. alexandercj@126.com.

Funding

National Natural Science Foundation of China 82104873Preparatory discipline leader training program of Shanghai TCM-Integrated hospital RCPY0071Xinglin Young Talent training Program of Shanghai University of Traditional Chinese Medicine RCPY0040
6 · The paper itself

Abstract

Baicalin, a bioactive flavonoid derived from Scutellaria baicalensis Georgi, epitomizes the ancient Chinese "medicine-food homology" (MFH) theory, serving dual roles in therapeutics and functional foods. This review synthesizes recent advances (2018-2024) on baicalin's multifaceted biological activities, pharmacological mechanisms, and emerging applications in food science. Structurally characterized by a flavone-7-O-glucoside backbone, baicalin exerts potent anti-inflammatory, antioxidant, antitumor, antiviral, and antimicrobial effects through modulation of key pathways, including NF-κB, Nrf2, TLR4/MyD88, and PI3K/AKT. Its anti-inflammatory action involves suppression of NLRP3 inflammasome activation and cytokine release, while its antioxidant capacity is mediated by Nrf2-driven detoxification. In food systems, baicalin enhances oxidative stress resistance in aquaculture feeds and improves hydrophobic nutraceutical bioavailability via nanoparticle encapsulation. Challenges such as low water solubility (0.5 mg/mL) and pH-dependent stability are addressed through innovative formulations, such as β-cyclodextrin complexes and ternary solvent systems, which enhance solubility by sevenfold. Network pharmacology and bioinformatics analyses reveal baicalin's multi-target engagement in cardiovascular, metabolic, and neurological disorders, underscoring its therapeutic versatility. Clinically, baicalin demonstrates cardioprotective, antidiabetic, and neuroprotective efficacy, while nano-delivery systems-including liposomes and metal-organic frameworks-overcome bioavailability limitations. This review bridges traditional MFH principles with cutting-edge research, positioning baicalin as a promising candidate for functional food development and preventive healthcare, aligned with global trends in natural product utilization and sustainable therapeutics.

Indexed as

FlavonoidsFunctional FoodAnimalsAnti-Inflammatory AgentsAntioxidantsHumansMedicine, TraditionalAnti-Inflammatory AgentsAntioxidantsbaicalinFlavonoidsAnti-inflammatoryBaicalinFunctional foodsMedicine-food homologyNetwork pharmacologyPharmacological effect

Identifiers

PMID40932545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.