ReviewMolecular biology reports2025
Modulation of nitric oxide signaling by flavonoids: implications for neurodegeneration.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exploring the Interplay of Antioxidants, Inflammation, and Oxidative Stress: Mechanisms, Therapeutic Potential, and Clinical Implications.Diseases (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The worldwide burden of neurodegenerative diseases (NDDs) has increased significantly during the last decades. Nitric oxide (*NO), a neurotransmitter, plays critical functions in the activation of numerous inflammatory processes. Although physiological *NO is required for protection against a wide range of infections, oxidative stress, and inflammatory cascades, excessive or dysregulated *NO production can contribute to cellular damage, exacerbating oxidative stress and inflammation, and potentially leading to various pathological conditions, including NDDs. Thus, reducing the overproduction of *NO is a promising treatment strategy for NDDs. Several substances have been investigated for the treatment of NDDs; however, they offer minimal clinical advantages and numerous side effects. Lifestyle modifications, particularly nutrition, can play a significant role in the battle against and prevention of various diseases. Natural flavonoids, a diverse class of chemicals containing phenolic groups found in numerous plants, have potential anti-oxidant, anti-inflammatory, and anti-apoptotic characteristics. The current review discusses the mechanism of *NO generation and its implication in NDDs via the modulation of molecular pathways by flavonoids to inhibit the *NO pathway.
Indexed as
Identifiers
40932522What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.