SynthesisGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025
Corneal biomechanical changes in patients with anterior chamber inflammation: a systematic review and meta-analysis.
Synthesis in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Impact of ultrasound cycloplasty on ocular biomechanics and refractive parameters: a comprehensive review.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAnterior chamber inflammation (ACI) causes corneal changes like band keratopathy, reduced endothelial cell density, and increased central corneal thickness (CCT). This review analyzes ACI's impact on corneal biomechanics.
methodsRegistered in PROSPERO (CRD42024584649) following PRISMA guidelines, systematic searches were conducted in PubMed, Embase, Virtual Health Library, and MedXRiv (May 2, 2024). Studies with ≥ 10 ACI patients were included. Data on corneal hysteresis (CH), corneal resistance factor (CRF), CCT, intraocular pressure (IOP): corneal-compensated (IOPcc) and Goldmann-correlated (IOPg) were extracted. Meta-analyses assessed mean differences and heterogeneity (I²), with sensitivity analyses for outliers and moderators (age, CCT). The Mann-Whitney U Test compared age, CCT, IOPg, and IOPcc between groups.
resultsThree studies comprising 126 ACI patients and 112 healthy controls were included. No significant differences were found between ACI patients and controls in age or CCT (p > 0.05). Meta-analyses revealed significant reductions in CH (-1.06 mmHg, 95% CI: -2.03 to -0.09, I²=83%) and CRF (-1.59 mmHg, 95% CI: -2.35 to -0.84, I²=69%) in ACI patients compared to controls. Sensitivity analysis showed that CCT as a moderator explained all the heterogeneity (R²=100%), while age did not (R²=0%). IOPg and IOPcc did not significantly differ among ACI patients (p = 0.051).
conclusionPatients with ACI exhibit significant reductions in corneal biomechanical properties (CH and CRF), with CRF consistently lower across all age groups. CCT significantly impacts corneal biomechanics, potentially making biomechanics alterations more evident during remission states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.