ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
Molecular Reactivity in Maternal Pregnancy Blood and Neonatal Dried Blood Spots Is Associated with the Risk of Pediatric Acute Lymphoblastic Leukemia.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Lauren M PetrickDepartment of Environmental Medicine, Icahn School of Medicine, Mount Sinai, New York, New York.ORCID 0000-0003-3493-7419
Partow ImaniDivision of Biostatistics, School of Public Health, University of California, Berkeley, California.ORCID 0009-0005-7885-8933
Miao YuDepartment of Environmental Medicine, Icahn School of Medicine, Mount Sinai, New York, New York.ORCID 0000-0002-2804-6014
Georgia DoliosDepartment of Environmental Medicine, Icahn School of Medicine, Mount Sinai, New York, New York.ORCID 0009-0008-2746-6317
Sandrine DudoitDivision of Biostatistics, School of Public Health, University of California, Berkeley, California.ORCID 0000-0002-6069-8629
Libby M MorimotoDivision of Epidemiology, School of Public Health, University of California, Berkeley, California.ORCID 0000-0002-1509-739X
Xiaomei MaDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.ORCID 0000-0001-9472-8032
Joseph L WiemelsCenter for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, California.ORCID 0000-0003-4838-9951
Catherine MetayerDivision of Epidemiology, School of Public Health, University of California, Berkeley, California.ORCID 0000-0003-3467-4145
Funding
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
Untargeted Analysis ResourceU2CES030859 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2019 to 2025
$8.2M
Project 3 - Prenatal Exposures, Constitutive Genetics, DNA Methylation & Childhood LeukemiaP50ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2015 to 2019
$3.8M
Project 3: Prenatal Exposure, DNA Methylation & Childhood LeukemiaP01ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2009 to 2013
$3.7M
Environmental chemical mixtures and metabolomics in autism spectrum disorderR01ES031117 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PETRICK, LAUREN · 2020 to 2024
$3.3M
Reconstructing early life environmental exposures using tooth biomarkers and their influence on the trajectory of the oral microbiome and oral health in childhoodR01DE029838 · NIDCR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ADLER, CHRISTINA JANE, PETRICK, LAUREN · 2020 to 2024
$3.3M
Perinatal immune development and risk of childhood acute lymphoblastic leukemiaR01CA175737 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2014 to 2018
$3.0M
Fetal Origins of Testicular Cancer: A Metabolomics Study in NewbornsUH2CA248974 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE, PETRICK, LAUREN · 2021 to 2022
$434k
National Cancer Institute (NCI) R01CA175737National Institute of Environmental Health Sciences (DEHS) P01ES018172National Institute of Environmental Health Sciences (DEHS) P50ES018172National Institutes of Health (NIH) P30ES023515National Institutes of Health (NIH) U2CES030859National Institutes of Health (NIH) UH2CA248974National Institutes of Health (NIH) UL1TR004419NCATS NIH HHS UL1 TR004419NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS R01 CA175737NCI NIH HHS UH2 CA248974NIDCR NIH HHS R01 DE029838NIEHS NIH HHS P01 ES018172NIEHS NIH HHS P30 ES023515NIEHS NIH HHS P50 ES018172NIEHS NIH HHS R01 ES031117NIEHS NIH HHS U2C ES030859U.S. Environmental Protection Agency (EPA) RD83451101U.S. Environmental Protection Agency (EPA) RD83615901
6 · The paper itself
Abstract
backgroundMost pediatric leukemia forms early in life, but early-life biology and biomarkers for screening remain undefined. We performed direct molecular measurements in neonatal dried blood spots (DBS) and maternal pregnancy serum to identify early-life biological signatures of pediatric acute lymphoblastic leukemia (ALL).
methodsIn a nested case-control study design, we obtained mother-infant paired samples from second-trimester pregnancy serum and neonatal DBS from 122 children diagnosed with pediatric ALL and 122 matched cancer-free controls. Using liquid chromatography-high-resolution mass spectrometry, we performed untargeted metabolomics. The data-driven Reactomics approach was used to identify quantitative paired mass differences (qPMD) that represent molecular changes in the samples. We identified qPMDs associated with ALL risk and assessed linolenic acid and linoleic acid as potential ALL biomarkers.
resultsOverall, the nine selected qPMDs in DBS were more strongly associated with ALL than the 16 qPMDs in maternal serum. Several of the selected qPMDs were highly correlated, suggesting that these qPMDs may represent biological reactivity hubs of metabolic pathways important in leukemogenesis. We also observed a suggestive positive but not significant association between linolenic acid and linoleic acid in the DBS of children diagnosed with ALL at 5 years or older (N = 13) and matched controls (N = 13).
conclusionsAlthough biological interpretation of Reactomics analysis for clinical intervention is currently limited, our study supports the presence of molecular reaction changes in early life associated with later pediatric ALL. IMPACT: Reactomics analysis revealed potential biomarkers in neonatal samples linked with later diagnosis of ALL.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Molecular Reactivity in Maternal Pregnancy Blood and Neonatal Dried Blood Spots Is Associated with the Risk of Pediatric Acute Lymphoblastic Leukemia. · full record | OpenQuestion