ArticleJournal of the American Heart Association2025
Single-Cell Transcriptomics of Human Pericarotid Lymph Nodes Indicating Stability of Carotid Atherosclerotic Plaques.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Monotropein mitigates atherosclerotic plaque vulnerability through circ_0140736/miR-495/SIRPα-mediated efferocytosis.iScience · 2026Article
- A single-cell and spatial atlas of plaque macrophage states in human atherosclerosis.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe link between lymph node (LN) function and atherosclerosis is unclear, especially at the single-cell level. This study explores the relationship between pericarotid LNs and plaque stability using single-cell transcriptome analysis.
methodsWe enrolled 106 patients with severe internal carotid artery stenosis undergoing carotid endarterectomy. We recorded baseline clinical data and pericarotid LN size, and analyzed plaque composition to assess its association with enlarged LNs. Single-cell transcriptome and T/B-cell receptor sequencing were used to profile pericarotid LNs.
resultsPatients with symptomatic carotid atherosclerosis had more enlarged pericarotid LNs (
conclusionsEnlarged pericarotid LNs are potential biomarkers for plaque instability and recent ischemic events. This study provides a comprehensive single-cell transcriptomic landscape of human LNs in atherosclerosis.
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