Evidence map›Paper›PMID 40931912›Full record

ReviewCancer2025

The 3P-CP model: Expanding our conceptualization of cancer pain.

Desiree R Azizoddin, Jian Zhao, Tamara J Somers, Sarah E Taylor, Joseph G Winger, Susan G Dorsey, Sarah Orris, Anaanya Nasta, Yael Schenker, Jessica S Merlin and 3 more

Abstract readReview
In one paragraph

Review in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Desiree R AzizoddinDepartment of Supportive Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-6993-1776
Jian ZhaoDepartment of Supportive Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1034-1741
Tamara J SomersDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-8809-2979
Sarah E TaylorDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Joseph G WingerPain Prevention and Treatment Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Susan G DorseyDepartment of Pain & Translational Symptom Science, University of Maryland School of Nursing, University of Maryland, Baltimore, Maryland, USA.
Sarah OrrisChallenges in Managing and Preventing Pain (CHAMPP) Clinical Research Center, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Anaanya NastaChallenges in Managing and Preventing Pain (CHAMPP) Clinical Research Center, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Yael SchenkerSection of Palliative Care and Medical Ethics, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jessica S MerlinChallenges in Managing and Preventing Pain (CHAMPP) Clinical Research Center, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Heather S L JimDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-7353-3711
Kristin L SchreiberDepartment of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Hailey W BullsChallenges in Managing and Preventing Pain (CHAMPP) Clinical Research Center, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1005-0303

Funding

Personalizing Perioperative Preventive Analgesia: Translational Studies Investigating the Biopsychosocial Underpinnings of Enhanced Pain PropensityR35GM128691 · NIGMS · STANFORD UNIVERSITY · PI KRISTIN SCHREIBER · 2018 to 2026
$4.3M
Integrating pain-CBT into an mHealth analgesic support intervention for patients withchronic pain from advanced cancersK08CA266937 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Desiree R Hilton · 2022 to 2026
$1.0M
Midcareer Investigator Award in Patient-Oriented Research: Yael Schenker, MD, MASK24AG070285 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHENKER, YAEL · 2021 to 2025
$841k
Mentoring the next generation of researchers at the intersection of opioid use disorder and chronic painK24DA056837 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Megan Hamm, Jessica S Merlin · 2023 to 2026
$771k
Development and piloting of an intervention to reduce the impact of opioid stigma in cancer painK08CA263317 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hailey Waddell Bulls · 2022 to 2026
$729k
NCI NIH HHS K08 CA263317NCI NIH HHS K08CA263317NCI NIH HHS K08 CA266937NCI NIH HHS K08CA266937NCI NIH HHS L30 CA242493NIA NIH HHS K24 AG070285NIA NIH HHS K24AG070285NIDA NIH HHS K24 DA056837NIDA NIH HHS K24DA056837NIGMS NIH HHS R35 GM128691NIGMS NIH HHS R35GM128691
6 · The paper itself

Abstract

Cancer pain is a complex, multifactorial, and growing public health challenge affecting millions of Americans. Effective pain management is essential for comprehensive cancer care, influencing physical and mental health, quality of life, and functional ability. However, progress in cancer pain management is hindered by the complexity of the issue and a fragmented understanding of the myriad factors shaping the pain experience. Additionally, traditional pain terminology-"acute" (<6 months) and "chronic" pain (≥6 months)-offers limited utility in cancer contexts, highlighting the need for a more nuanced framework. To address this gap, we propose the 3P-CP model, which conceptualizes cancer pain through three interconnected phases: predisposing factors that increase cancer pain risk, precipitating factors that trigger cancer pain onset, and perpetuating factors that sustain or exacerbate cancer pain over time. This model provides a structured approach to assess the dynamic nature of cancer pain across the entirety of the cancer trajectory. In this paper, key factors associated with each phase of the 3P-CP model are outlined and their implications for research and clinical care explored. Aligning with the oncology field's shift toward precision medicine, the 3P-CP model has the potential to guide comprehensive assessment, risk mitigation, prevention, and intervention strategies-supporting efforts to deliver the right targeted and tailored treatments, to the right patients, at the right time.

Indexed as

Cancer PainChronic PainNeoplasmsPain ManagementHumansQuality of Lifecancer painconceptual frameworkpain managementprecision medicinesurvivorship

Identifiers

PMID40931912
PMCPMC12424019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.