Evidence map›Paper›PMID 40931865›Full record

ArticleAutophagy2025

Evolutionary diversification of the autophagy initiation complex: reduced Atg101 dependency and changes in Atg9 binding to Atg13.

Zefeng Lai, Yutaro Hama, Masahide Oku, Sidi Zhang, Yasuyoshi Sakai, Hayashi Yamamoto, Noboru Mizushima

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zefeng LaiDepartment of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0009-0004-0539-2821
Yutaro HamaDepartment of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-7190-4547
Masahide OkuDepartment of Bioscience and Biotechnology, Faculty of Bioenvironmental Science, Kyoto University of Advanced Science, Kyoto, Japan.ORCID 0000-0001-5991-6281
Sidi ZhangDepartment of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-1993-085X
Yasuyoshi SakaiDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.ORCID 0000-0002-9831-3085
Hayashi YamamotoDepartment of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-2831-1463
Noboru MizushimaDepartment of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-6258-6444

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macroautophagy/autophagy is an evolutionarily conserved process through which cells degrade cytoplasmic substances via autophagosomes. During the initiation of autophagosome formation, the ULK/Atg1 complex serves as a scaffold that recruits and regulates downstream ATG/Atg proteins and ATG9/Atg9-containing vesicles. Despite the essential role of the ULK/Atg1 complex, its components have changed during evolution; the ULK complex in mammals consists of ULK1 (or ULK2), RB1CC1, ATG13, and ATG101, whereas the Atg1 complex in the yeast

Indexed as

Adaptor Proteins, Vesicular TransportAutophagyAutophagy-Related ProteinsEvolution, MolecularMembrane ProteinsSaccharomyces cerevisiae ProteinsAnimalsAutophagosomesHumansPhylogenyProtein BindingSaccharomyces cerevisiaeVesicular Transport ProteinsAdaptor Proteins, Vesicular TransportATG9 protein, S cerevisiaeAutophagy-Related ProteinsMembrane ProteinsSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsAtg13-Atg9 interactionAtg29-Atg31 subcomplexKomagataella phaffiiPAS formationSaccharomyces cerevisiaeULK/Atg1 complex

Identifiers

PMID40931865
PMCPMC12758289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.