Evidence map›Paper›PMID 40931826›Full record

ArticleStroke2025

Major ABO-Incompatible Platelet Transfusions Are Associated With Brain Ischemia After Intracerebral Hemorrhage.

Fernanda Carvalho Poyraz, Mohamed Ridha, Marialaura Simonetto, Aditya Kumar, Shivani Ghoshal, Sachin Agarwal, Soojin Park, Jan Claassen, E Sander Connolly, Elizabeth F Stone and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fernanda Carvalho PoyrazDepartment of Neurology (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0003-2488-6849
Mohamed RidhaDepartment of Neurology (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0002-0814-0222
Marialaura SimonettoDepartment of Neurology (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.), Vagelos College of Physicians and Surgeons, Columbia University, New York.
Aditya KumarDepartment of Neurology (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0009-0003-1544-8844
Shivani GhoshalDepartment of Neurology (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.), Vagelos College of Physicians and Surgeons, Columbia University, New York.
Sachin AgarwalDepartment of Neurology (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0003-0559-9326
Soojin ParkDepartment of Neurology (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0002-3688-7307
Jan ClaassenDepartment of Neurology (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0002-5893-8531
E Sander ConnollyDepartment of Neurosurgery (E.S.C.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0002-6877-3371
Elizabeth F StoneDepartment of Pathology (E.F.S.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0002-4148-7957
David J RohDepartment of Neurology (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0003-1927-7686

Funding

REDS-IV-P DOMESTIC HUBS PHASE 275N92019D00037 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOD, ELDAD ARIE · 2019 to 2024
$6.6M
FunctIonal coaGulation and HemosTasis after IntraCerebral Hemorrhage (FIGHT-ICH)R01HL173606 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David Roh · 2025 to 2026
$1.6M
Erythrocyte contribution to coagulopathy and cerebral oxygenation after intracerebral hemorrhageK23HL151901 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROH, DAVID · 2021 to 2025
$950k
NHLBI NIH HHS 75N92019D00037NHLBI NIH HHS K23 HL151901NHLBI NIH HHS R01 HL173606NINDS NIH HHS L30 NS103293
6 · The paper itself

Abstract

backgroundMajor ABO-incompatible platelet transfusions are associated with poor intracerebral hemorrhage (ICH) outcomes, yet drivers for this relationship remain unclear. Brain magnetic resonance imaging (MRI) ischemic lesions after ICH are neuroimaging biomarkers of secondary brain injury and are associated with poor outcomes. Given that ABO-incompatible platelet transfusions can induce immune complex formation, thrombo-inflammation, and endothelial barrier disruption, factors that could exacerbate cerebral ischemia, we explored whether major ABO-incompatible platelet transfusions are risk factors for ischemic lesions on brain MRI after ICH.

methodsAdult patients admitted to a tertiary-care academic center between 2009 and 2016 who received a single-platelet transfusion within 24 hours of admission after an ICH, had available donor/recipient ABO data, and brain MRI during the hospitalization were analyzed. Adjusted regression models evaluated relationships between major ABO-incompatible platelet units and MRI ischemic lesions.

resultsA total of 40 patients were included in the study. The mean age was 67.1 (SD, 14.1), and 37.5% were female. Twenty percent of patients received a major ABO-incompatible platelet unit. Major ABO-incompatible platelet transfusions were associated with increased odds of MRI ischemic lesions after adjusting for ICH severity (adjusted odds ratio, 9.2 [95% CI, 1.3-62.7]).

conclusionsOur exploratory findings suggest that major ABO-incompatible platelet transfusions may contribute to secondary brain injury after ICH. Further work is needed to assess whether avoiding major ABO-incompatible platelet transfusions can prevent secondary brain injury burden and improve ICH outcomes.

Indexed as

ABO Blood-Group SystemBlood Group IncompatibilityBrain IschemiaCerebral HemorrhagePlatelet TransfusionAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesRisk FactorsABO Blood-Group Systemblood pressureinflammationmagnetic resonance imagingneuroimagingplatelet transfusion

Identifiers

PMID40931826
PMCPMC12614746

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.