Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Cameron A BeecheDepartment of Bioengineering (C.A.B.), University of Pennsylvania, Philadelphia.ORCID 0000-0002-5781-8810
Hamed TavolinejadDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia (C.A.B., H.T., J.A.C.).ORCID 0000-0002-0244-5914
Bingxin ZhaoDepartment of Statistics and Data Science (B.Z.), University of Pennsylvania, Philadelphia.
Patrick SegersInstitute of Biomedical Engineering and Technology, Ghent University, Belgium (P.S.).ORCID 0000-0003-3870-3409
Jeffrey T DudaDepartment of Radiology, Perelman School of Medicine (J.T.D., J.G., W.R.W.), University of Pennsylvania, Philadelphia.ORCID 0000-0002-5031-5735
James GeeDepartment of Radiology, Perelman School of Medicine (J.T.D., J.G., W.R.W.), University of Pennsylvania, Philadelphia.ORCID 0000-0002-2258-0187
Walter R WitscheyDepartment of Radiology, Perelman School of Medicine (J.T.D., J.G., W.R.W.), University of Pennsylvania, Philadelphia.ORCID 0000-0003-1669-2120
Penn Medicine Biobank*
Julio A ChirinosDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia (C.A.B., H.T., J.A.C.).ORCID 0000-0001-9035-5670
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4M
Understanding the relationship between obesity and tongue fat in humans and ratsP01HL094307 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 2009 to 2020
$23.7M
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
VASCULAR EFFECTS OF DIETARY SALT IN HUMANS WITH SALT-RESISTANT BPR01HL104106 · NHLBI · UNIVERSITY OF DELAWARE · PI EDWARDS, DAVID G, FARQUHAR, WILLIAM B · 2011 to 2021
$4.5M
Targeting Skeletal Muscle Perfusion and Oxidative Capacity in HFpEFR01HL155599 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ZAMANI, PAYMAN · 2021 to 2025
$3.9M
Cardiovascular Risk, Vascular and Kidney Damage in COVID-19 SurvivorsR01HL157108 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JULIO ALONSO CHIRINOS MEDINA, Jordana B. Cohen · 2022 to 2026
$3.9M
Blockade of calcium channels and beta adrenergic receptors for physiologic abnormalities in heart failure with preserved ejection fraction (BLOCK HFpEF)R01HL153646 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI COHEN, JORDANA B. · 2020 to 2024
$3.2M
Efficacy of Potassium Nitrate in Heart Failure with Preserved Ejection FractionR01HL121510 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2015 to 2019
$3.1M
Cardiovascular Consequences of Duchenne and Becker Muscular DystrophinopathiesR01HL155764 · NHLBI · UNIVERSITY OF DELAWARE · PI WITMAN, MELISSA A.H. · 2021 to 2025
$3.1M
Non-invasive imaging of reactive oxygen species in reperfusion injury myocardial infarctionR01HL169378 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACO E. BRAVO, Walter R.T. Witschey · 2023 to 2026
$3.0M
Cardiac MR imaging of hemorrhagic reperfusion injury after myocardial infarctionR01HL137984 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WITSCHEY, WALTER R.T. · 2018 to 2022
backgroundAortic structural degeneration occurs with aging; however, 3-dimensional geometric remodeling has not been well characterized in large populations.
methodsWe segmented the thoracic aorta from magnetic resonance images of 56 164 UKB (UK Biobank) participants and computed tomography images of 9417 PMBB (Penn Medicine Biobank) participants. We quantified structural measurements of elongation, dilation, tortuosity, and curvature across the thoracic aorta. Multivariate linear regression models estimated the associations between age and aortic structure in a subset of normative healthy participants from the UKB (n=3532), and in the overall cohorts.
resultsPatterns of aging were highly consistent between the UKB and PMBB. In the UKB normative subset, aging was associated with profound geometric changes, including elongation (β per decade of age, 1.001 cm [95% CI, 0.893-1.110];
conclusionsAging is associated with profound 3-dimensional geometric changes in the thoracic aorta, including elongation, luminal dilation, and decreased curvature. Females demonstrate less eccentric aortic remodeling and more pronounced changes in curvature, likely contributing to unfavorable pulsatile arterial hemodynamics that are present in older females.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Geometric Aging of the Thoracic Aorta: Insights From 2 Large Cohorts. · full record | OpenQuestion