ArticleJournal of cosmetic dermatology2025
In Vitro Evaluation of the Effects of Multipoint Hyaluronic Acid-Based Intradermal Fillers on Skin Quality Using a Novel 3D Reconstructed Skin Aging Model.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Biogenic Carbon Dots From Hyaluronic Acid and Opuntia humifusa (Eastern Prickly Pear Cactus) for Enhanced Antioxidant Protection and Skin Hydration: An In Vitro Study.Applied biochemistry and biotechnology · 2026Article
- Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study.Plastic and reconstructive surgery. Global open · 2026Article
- Remodeling Effect of HA Hybrid Cooperative Complexes on Dermal White Adipose Tissue and Its Structure.Clinical, cosmetic and investigational dermatology · 2026Article
- The Tripartite Regulatory Framework of the Skin Extracellular Microenvironment and Related Anti-aging Strategies.Mini reviews in medicinal chemistry · 2026Review
- In Vitro Evaluation of the Effects of Multipoint Hyaluronic Acid-Based Intradermal Fillers on Skin Quality Using a Novel 3D Reconstructed Skin Aging Model.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundSuperficial injection of hyaluronic acid (HA)-based gels is a widely used method to restore skin quality and achieve a more youthful appearance. While the clinical benefits of such procedures are well established, their biological mechanisms of action remain poorly understood.
objectiveThis study aimed to evaluate the effectiveness of two cross-linked HA gels (IPN-12.5 and HA-X12) on skin rejuvenation, focusing on skin hydration and extracellular matrix quality. The evaluation was conducted using an innovative skin model that closely mimics native human skin. MATERIAL AND
methodsA bioengineered scaffold composed of collagen, glycosaminoglycans, and chitosan was developed and seeded with aged human fibroblasts. This seeded scaffold has the ability to allow cellular migration, proliferation, and neo-synthesize its own extracellular matrix. Normal human keratinocytes were subsequently seeded on top of the newly formed dermal equivalent, thereby simulating the complex interactions that occur between the epidermis and dermis. Multipoint intradermal injections of the test products were administrated using a multipoint technique during the reconstruction protocol.
resultsBoth products significantly decreased transepidermal water loss (TEWL), though histomorphological differences were observed. The IPN-12.5-hydrogel-injected models showed enhanced barrier integrity, water retention, epidermal renewal, and skin elasticity markers compared to the controls and HA-X12.
conclusionIPN-12.5 hydrogel significantly improved hydration and elasticity-related skin markers when compared to a similar product (HA-X12). Despite similar clinical indications and concentrations, the products exhibited different biological effects, potentially due to differences in cross-linking technologies or HA molecular weights. These factors are likely to influence clinical outcomes achieved with the two formulations.
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Registered trials
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