Evidence map›Paper›PMID 40931717›Full record

ArticleLab on a chip2025

Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip.

Edmond A Rogers, Tyler C Diorio, Timothy Beauclair, Jhon Martinez, Shatha J Mufti, David Kim, Nikita Krishnan, Vitaliy Rayz, Riyi Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Edmond A RogersWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. vrayz@purdue.edu.ORCID 0000-0002-0617-0719
Tyler C DiorioWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. vrayz@purdue.edu.
Timothy BeauclairWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. vrayz@purdue.edu.
Jhon MartinezWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. vrayz@purdue.edu.ORCID 0009-0007-3762-3446
Shatha J MuftiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. vrayz@purdue.edu.
David KimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. vrayz@purdue.edu.
Nikita KrishnanWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. vrayz@purdue.edu.
Vitaliy RayzWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. vrayz@purdue.edu.
Riyi ShiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. vrayz@purdue.edu.ORCID 0000-0002-7297-9428

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
NCATS NIH HHS UL1 TR002529
6 · The paper itself

Abstract

Traumatic brain injuries (TBIs) are a risk factor for Alzheimer's disease (AD), and share several important pathological features including the development of neurofibrillary tangles (NFT) of tau protein. While this association is well established, the underlying pathogenesis is poorly defined and current treatment options remain limited, necessitating novel methods and approaches. In response we developed "TBI-on-a-chip", an

Indexed as

AcroleinBrain ConcussionDendritic SpinesLab-On-A-Chip DevicesNeuronstau ProteinsAnimalsMiceOxidative StressAcroleintau Proteins

Identifiers

PMID40931717
PMCPMC12423756

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.