SynthesisAnnals of medicine2025
Prognostic values and clinical significance of POU2F3 expression in neuroendocrine carcinomas: a meta-analysis with a focus on small cell lung cancer.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSmall cell lung cancer (SCLC) is a highly aggressive neuroendocrine carcinoma (NEC) with poor prognosis due to chemotherapy resistance. Molecular subtypes, including ASCL1, NEUROD1, YAP1 and POU2F3, have distinct clinical implications. POU2F3, linked to a tuft cell-like lineage, represents a non-neuroendocrine subtype found in SCLC and extrapulmonary NECs. However, its prognostic and clinical significance remain unclear.
methodsA meta-analysis was performed to assess the relationship between POU2F3 expression and clinical outcomes in SCLC and NECs. Studies reporting clinicopathological or survival data related to POU2F3 expression, identified
resultsSixteen studies involving 2011 patients met inclusion criteria. Pooled analysis revealed that POU2F3 expression in SCLC significantly improved OS (HR = 0.74, 95% CI = 0.61-0.90,
conclusionPOU2F3 expression is associated with improved survival and correlates with younger age and male sex in SCLC, highlighting distinct clinical and biological characteristics of this tuft cell-originated subtype. Data on extrapulmonary NECs were limited, precluding definitive conclusions for this population.
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