ArticleBrain and behavior2025
An Association Analysis of Anxiety and Psoriasis: Based on the NHANES Database.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- An Association Analysis of Anxiety and Psoriasis: Based on the NHANES Database.Brain and behavior · 2025Article
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2 authors.
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Abstract
backgroundPsoriasis is linked with an elevated risk of anxiety disorders, and there may be a temporal relationship between the two. However, the association between anxiety status and its duration with psoriasis is unclear.
objectivesThe present work aimed to figure out the association between anxiety and the risk of psoriasis.
methodsData from the National Health and Nutrition Examination Survey (NHANES) 2009-2012 were used. Anxiety state and days of anxiety were applied as the independent variables, and psoriasis as the dependent variable. Weighted logistic regression was employed to analyze the connection between the state and days of anxiety with psoriasis. Restricted cubic spline (RCS) was further utilized to dig out the nonlinear association between days of anxiety and psoriasis. By using weighted logistic regression to further explore the correlation between the combination of anxiety and common cardiovascular risk factors (smoking, hypertension, CVD events) and the risk of psoriasis. Finally, a weighted logistic regression model was constructed for different genders and alcohol consumption subgroups to explore the association between anxiety status and anxiety days and psoriasis and to evaluate the differences in association among different groups.
resultsA total of 8888 participants were included in this project, among whom 265 cases (3.1%) were psoriasis patients. Through the weighted logistics regression model, we observed a significant positive correlation between anxiety (OR: 1.439, 95% CI: 1.008-2.053, p = 0.030), number of days with anxiety (OR: 1.018, 95% CI: 1.002-1.033, p = 0.014), and the risk of psoriasis in patients. The RCS curve results indicated a linear positive correlation between anxiety days and the risk of psoriasis (p-nonlinear = 0.162). The results of the joint analysis demonstrated that anxiety
conclusionAnxiety and the number of days with anxiety are positively linked with the risk of psoriasis. Individuals with anxiety
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