Evidence map›Paper›PMID 40931490›Full record

ArticleAging cell2025

Entropy, Assessed by Homeostatic Dysregulation on Electrocardiograms Predicts Fracture and Mortality.

Namki Hong, Sang Wouk Cho, Jungheui Kim, Hanjin Park, Dong-Seon Kang, Seng Chan You, Hee Tae Yu, Kyoung Min Kim, Yumie Rhee, Alan A Cohen and 1 more

Abstract read
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Aging as Entropy: A Quantifiable Framework.Endocrinology and metabolism (Seoul, Korea) · 2025
    Article
  5. Entropy and Human Aging.Aging cell · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Namki HongDivision of Endocrinology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.ORCID 0000-0002-8246-1956
Sang Wouk ChoInstitute for Innovation in Digital Healthcare (IIDH), Yonsei University Health System, Seoul, Korea.
Jungheui KimInstitute for Innovation in Digital Healthcare (IIDH), Yonsei University Health System, Seoul, Korea.
Hanjin ParkDivision of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Dong-Seon KangDivision of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Seng Chan YouInstitute for Innovation in Digital Healthcare (IIDH), Yonsei University Health System, Seoul, Korea.ORCID 0000-0002-5052-6399
Hee Tae YuDivision of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Kyoung Min KimDivision of Endocrinology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.
Yumie RheeDivision of Endocrinology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Alan A CohenDepartment of Environmental Health Sciences, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, New York, USA.ORCID 0000-0003-4113-3988
Steven R CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.

Funding

Korea Health Industry Development Institute HI22C0452
6 · The paper itself

Abstract

Entropy, characterized by increased disorder throughout biological systems, can be quantified by homeostatic dysregulation (HD). One potential measure of HD is the dispersion of points from a normal value, approximated at the individual level by Mahalanobis distance (D

Indexed as

ElectrocardiographyEntropyFractures, BoneHomeostasisAdultAgedFemaleHumansMaleMiddle AgedRisk Factorsagingelectrocardiographyentropyhomeostasismortalityrisk

Identifiers

PMID40931490
PMCPMC12686576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.