Evidence map›Paper›PMID 40931463›Full record

ArticleInternational journal of cosmetic science2026

New alternatives in photoprotection: Preparation and evaluation of lamellar silicate derivatives and their use as sunscreens.

Daniel Mabundu Kibwila, Alice Simon, Letícia Coli Louvisse de Abreu, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Marcelo de Pádula, Lucio Mendes Cabral

Abstract read
In one paragraph

Article in International journal of cosmetic science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel Mabundu KibwilaDepartment of Pharmaceutics and Medicines, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-2930-1355
Alice SimonDepartment of Pharmaceutics and Medicines, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-4673-6182
Letícia Coli Louvisse de AbreuLaboratory of Instrumental Analysis, Duque de Caxias Campus, Federal Institute of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-3616-3667
Carlos Rangel RodriguesDepartment of Pharmaceutics and Medicines, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Valeria Pereira de SousaDepartment of Pharmaceutics and Medicines, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-1589-0846
Marcelo de PádulaDepartment of Pharmaceutics and Medicines, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-0341-1369
Lucio Mendes CabralDepartment of Pharmaceutics and Medicines, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-4550-5729

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
6 · The paper itself

Abstract

objectiveThe objective of this work is to investigate different sunscreens and Viscogel group organoclays for the preparation of new intercalated sunscreens to improve the effectiveness and safety in photoprotection using new approach methodology (NAMs).

methodsFor this study, we examined Diethylamino hydroxybenzoyl hexyl benzoate (DHHB), octyl methoxycinnamate (OMC), Bemotrizinol (BEMT) and Viscogel S4®, S7®, and B8® using a set of Saccharomyces cerevisiae mutant strains that are sensitive to UVA, UVB and Solar Simulated Light (SSL) to evaluate their photoprotective and mutagenic potential. Additionally, we developed delaminated nanocomposites by chemical intercalation reactions followed by ultrasonic treatment to enhance clay exfoliation. These nanocomposites were then characterized using X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA) and Dynamic Light Scattering (DLS).

resultsAs a function of photoprotective action and safety, the combination of Viscogel S4® and OMC filter was chosen for nanocomposite development. Our results evidenced the intercalation of the OMC in the organoclay (S4 + OMC-NC). Survival and mutagenesis tests indicated a positive effect of the formulation, as it increased cell survival to SSL, even without reducing mutagenesis, while its respective physical mixture was unable to provide antimutagenic protection.

conclusionS4 + OMC-NC showed promising results for photoprotection, offering cellular protection combined with antimutagenic effects upon SSL exposure. This formulation enables prospects for the preparation of new, effective and safe photoprotective formulations.

Indexed as

SilicatesSunscreening AgentsCalorimetry, Differential ScanningSaccharomyces cerevisiaeUltraviolet RaysX-Ray DiffractionSilicatesSunscreening Agentsnanocompositenew approach methodologyoctyl methoxycinnamate (OMC)photoprotectionsafety testingViscogel S4®

Identifiers

PMID40931463
PMCPMC12877990

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.