ArticleObesity (Silver Spring, Md.)2025
Exploring Organ-Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity.
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Advancements in extracellular vesicle research.Extracellular vesicle · 2026Article
- Exploring Organ-Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity.Obesity (Silver Spring, Md.) · 2025Article
- Systematic Review: Exosomes as Molecular Messengers in the Development of Obesity-Related Complications in Children.Current issues in molecular biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectiveVertical sleeve gastrectomy (VSG) promotes significant metabolic improvements, though the underlying molecular mechanisms are not fully understood. Emerging evidence suggests that small extracellular vesicles (sEVs) contribute to metabolic improvements post VSG, such as improved fatty liver disease or adipose tissue function; however, it is unclear how different organ-specific sEVs interact with various metabolic parameters. The objective of this study is to establish the role of organ-specific sEVs in the metabolic improvements post VSG.
methodsDemographic and anthropometric data, metabolic parameters, and sEV samples were collected pre VSG and 3-6 months post VSG in youth with obesity. sEV RNA was sequenced for bioinformatics analyses.
resultsA significant reduction of the liver-enriched mRNA cargo in sEVs was observed post VSG, whereas adipose-enriched mRNA cargo showed no such reduction. Liver-enriched mRNA cargo correlated with BMI, leptin, and resistin 6 months post VSG. Analysis of delta values (post minus pre surgery) revealed that adipose-enriched mRNA cargo correlated with markers of liver damage, whereas liver-derived mRNA cargo correlated with branched-chain amino acids.
conclusionsFollowing VSG, significant changes occur in the liver-enriched mRNA cargo of sEVs. Liver-derived sEVs appear to influence adipose metabolism, whereas adipose-derived sEVs are linked with liver function, suggesting dynamic intertissue cross talk that shapes systemic metabolic outcomes.
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Registered trials
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