Evidence map›Paper›PMID 40931325›Full record

ArticleMagnetic resonance in chemistry : MRC2025

Tutorial: Saturation Transfer Difference NMR for Studying Small Molecules Interacting With Nanoparticles.

Sekinah O Dauda, Rajan Rai, Stephanie P Palma, Hui Xu, Leah B Casabianca

Abstract read
In one paragraph

Article in Magnetic resonance in chemistry : MRC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sekinah O DaudaDepartment of Chemistry, Clemson University, Clemson, South Carolina, USA.ORCID https://orcid.org/0009-0009-8659-2265
Rajan RaiDepartment of Chemistry, Clemson University, Clemson, South Carolina, USA.ORCID https://orcid.org/0000-0001-5798-7983
Stephanie P PalmaDepartment of Chemistry, Clemson University, Clemson, South Carolina, USA.
Hui XuDepartment of Chemistry, Clemson University, Clemson, South Carolina, USA.
Leah B CasabiancaDepartment of Chemistry, Clemson University, Clemson, South Carolina, USA.ORCID https://orcid.org/0000-0001-9447-3236

Funding

NSF CHE-2304888
6 · The paper itself

Abstract

Saturation transfer difference (STD) NMR is a robust, versatile technique for detecting small molecules binding to large receptors. In addition to identifying binding molecules in the presence of nonbinding molecules, the STD-NMR technique can be used to determine epitope maps and binding constants. In recent years, this technique has been applied to small molecules interacting with nanoparticles. In this tutorial, we introduce the technique of STD-NMR and how it can be used to gain information about small molecules interacting with nanoparticle surfaces. After describing the principle of the STD-NMR technique, we will explain how to best prepare the sample, set up the experiment, and analyze the resulting data when nanoparticles are involved. We will also present extensions to the STD-NMR technique, alternative approaches for when STD-NMR is not ideal, and future directions for the field.

Indexed as

1HnanoparticleNMRsaturation transfer differencetutorial

Identifiers

PMID40931325
PMCPMC12583243

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.