Evidence map›Paper›PMID 40931294›Full record

ArticleClinical journal of gastroenterology2025

A case of successful pembrolizumab plus FP neoadjuvant chemotherapy for a tumor preoperatively diagnosed as gastric squamous cell carcinoma.

Sho Fukuda, Shinichiro Atsumi, Ryo Ookubo, Kenta Watanabe, Yosuke Shimodaira, Yuko Hiroshima, Tamotsu Matsuhashi, Hiroshi Nanjo, Junichi Arita, Katsunori Iijima

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In one paragraph

Article in Clinical journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sho FukudaDepartment of Gastroenterology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita City, Akita, Japan. s.fukuda@med.akita-u.ac.jp.ORCID http://orcid.org/0000-0001-8708-0645
Shinichiro AtsumiDepartment of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita City, Akita, Japan.
Ryo OokuboDepartment of Gastroenterology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita City, Akita, Japan.
Kenta WatanabeDepartment of Gastroenterology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita City, Akita, Japan.
Yosuke ShimodairaDepartment of Gastroenterology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita City, Akita, Japan.
Yuko HiroshimaDepartment of Pathology, Akita University Hospital, Akita City, Akita, Japan.
Tamotsu MatsuhashiDepartment of Gastroenterology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita City, Akita, Japan.
Hiroshi NanjoDepartment of Pathology, Akita University Hospital, Akita City, Akita, Japan.
Junichi AritaDepartment of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita City, Akita, Japan.
Katsunori IijimaDepartment of Gastroenterology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita City, Akita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary gastric squamous cell carcinoma (GSCC) or gastric adenosquamous carcinoma (GASC) is an uncommon histologic type for which no standard treatment has been established. The prognosis is poor, and there are few reports of effective treatment. Here, we experienced a case of GASC that was diagnosed preoperatively as GSCC and could be operated on after successful preoperative chemotherapy with pembrolizumab, 5-fluorouracil, and cisplatin. Although it is challenging to differentiate GSCC from GASC preoperatively, we report a case that may help select preoperative chemotherapy.

Indexed as

Antibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, AdenosquamousCarcinoma, Squamous CellNeoadjuvant TherapyStomach NeoplasmsCisplatinFemaleFluorouracilHumansMaleMiddle AgedAntibodies, Monoclonal, HumanizedCisplatinFluorouracilpembrolizumabGastric adenosquamous cell carcinomaGastric squamous cell carcinomaICIPembrolizumab

Identifiers

PMID40931294

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.