RF phase modulation improves quantitative transient state sequences under constrained conditions.

Miha Fuderer, Hongyan Liu, Oscar van der Heide, Cornelis A T van den Berg, Alessandro Sbrizzi

Abstract read

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Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Miha FudererComputational Imaging Group for MR Diagnostics & Therapy, Center for Image Sciences, University Medical Center Utrecht, Heidelberglaan 100, 3585CX, Utrecht, The Netherlands. m.fuderer@umcutrecht.nl.ORCID http://orcid.org/0000-0002-5673-915X

Hongyan LiuComputational Imaging Group for MR Diagnostics & Therapy, Center for Image Sciences, University Medical Center Utrecht, Heidelberglaan 100, 3585CX, Utrecht, The Netherlands.

Oscar van der HeideComputational Imaging Group for MR Diagnostics & Therapy, Center for Image Sciences, University Medical Center Utrecht, Heidelberglaan 100, 3585CX, Utrecht, The Netherlands.

Cornelis A T van den BergComputational Imaging Group for MR Diagnostics & Therapy, Center for Image Sciences, University Medical Center Utrecht, Heidelberglaan 100, 3585CX, Utrecht, The Netherlands.

Alessandro SbrizziComputational Imaging Group for MR Diagnostics & Therapy, Center for Image Sciences, University Medical Center Utrecht, Heidelberglaan 100, 3585CX, Utrecht, The Netherlands.

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 17986

6 · The paper itself

Abstract

objectiveWithin gradient-spoiled transient-state MR sequences like Magnetic Resonance Fingerprinting or Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT), it is examined whether an optimized RF phase modulation can help to improve the precision of the resulting relaxometry maps.

methodsUsing a Cramer-Rao based method called BLAKJac, optimized sequences of RF pulses have been generated for two scenarios (amplitude-only modulation and amplitude + phase modulation) and for several conditions. These sequences have been tested on a phantom, a healthy human brain and a healthy human leg, to reconstruct parametric maps (

resultsThe amplitude + phase modulation scenario systematically resulted in lower noise levels than the amplitude-only modulation scenario. On average, the difference was around 34%, but it was substantially larger for scans acquired under SAR restrictions. Compared to amplitude-only, in the amplitude + phase modulation scenario, the relevance of an inversion pulse and of a pause were greatly reduced, at least considering overall precision and in-phantom accuracy.

conclusionThe application of an optimized RF phase modulation in quantitative transient-states MRI is beneficial for almost all tested scenarios and conditions, in particular under SAR restrictions Furthermore, RF phase modulation reduces the need for inversions pulses and pauses.

Indexed as

Magnetic Resonance ImagingAlgorithmsBrainHumansImage Processing, Computer-AssistedLegPhantoms, ImagingRadio WavesReproducibility of ResultsSignal-To-Noise RatioMR-STATMultiparametric magnetic resonance imagingQuantitative MRIRF phase modulationSequence optimization

Identifiers

PMID40931283

DOI10.1007/s10334-025-01293-9

PMCPMC12901244

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.