Evidence map›Paper›PMID 40931251›Full record

ArticleUrolithiasis2025

Do elevated intrarenal pressures during mini percutaneous nephrolithotomy increase postoperative pain??

Ziv Savin, Kavita Gupta, Christopher Connors, Yuval Elkun, Eve Frangopoulos, Raymond Khargi, Vinay Durbhakula, Blair Gallante, William M Atallah, Mantu Gupta

Abstract read
PubMed Publisher
In one paragraph

Article in Urolithiasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ziv SavinDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States. zivsavin23@gmail.com.
Kavita GuptaDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.
Christopher ConnorsDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.
Yuval ElkunDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.
Eve FrangopoulosDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.
Raymond KhargiDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.
Vinay DurbhakulaDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.
Blair GallanteDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.
William M AtallahDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.
Mantu GuptaDepartment of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHigh intrarenal pressures (IRP) during mini-PCNL have been postulated to result in increased postoperative pain but no studies have evaluated this to our knowledge. We sought to determine if there is a correlation between IRP and immediate postoperative pain when using different tract sizes.

methodsPatients were enrolled and assigned for standard (s-PCNL, 24fr), suctioning-mini (sm-PCNL, 16fr) and non-suctioning-mini (nsm-PCNL, 17.5fr) PCNLs. IRP was measured continuously with a novel technique of real-time monitoring using a 0.014 single-use pressure-sensing COMET™ guidewire. Postoperative pain was documented at the PACU using the VAS pain score. Correlation tests were used to evaluate the association between maximal IRP or tract size and postoperative pain.

resultsThe study cohort consisted of 30 patients with 10 patients in each group. The median age was 59 and the median stone volume was 438 mm

conclusionThe IRP range during PCNL is relatively low, regardless of the tract size. There was no association between the level of maximal IRP and postoperative pain. Our findings provide new in-vivo evidence challenging the commonly cited 30 mmHg IRP threshold and support its reevaluation, given the lack of strong clinical validation.

Indexed as

Kidney CalculiNephrolithotomy, PercutaneousPostoperative PainAgedFemaleHumansKidneyMaleMiddle AgedPain MeasurementPressureIntrarenal pressureMini-PCNLPercutaneous nephrolithotomyPostoperative pain

Identifiers

PMID40931251

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.