ArticleNature neuroscience2025
Grid cells accurately track movement during path integration-based navigation despite switching reference frames.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Two-Dimensional Grid-Cell Code for Three-Dimensional Navigation in Freely Flying Bats.bioRxiv : the preprint server for biology · 2026Article
- Maintaining and regaining episodic memory in Alzheimer disease: a circuit-based perspective.Nature reviews. Neurology · 2026Review
- Grid cells go local.Nature reviews. Neuroscience · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Grid cells, with their periodic firing fields, are fundamental units in neural networks that perform path integration. It is widely assumed that grid cells encode movement in a single, global reference frame. In this study, by recording grid cell activity in mice performing a self-motion-based navigation task, we discovered that grid cells did not have a stable grid pattern during the task. Instead, grid cells track the animal movement in multiple reference frames within single trials. Specifically, grid cells reanchor to a task-relevant object through a translation of the grid pattern. Additionally, the internal representation of movement direction in grid cells drifted during self-motion navigation, and this drift predicted the mouse's homing direction. Our findings reveal that grid cells do not operate as a global positioning system but rather estimate position within multiple local reference frames.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.