Evidence map›Paper›PMID 40931150›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2026

Clinical features of Barrett's mucosa arising in the remnant esophagus after subtotal esophagectomy and esophago-gastric anastomosis for esophageal cancer.

Masanobu Nakajima, Masatoshi Nakagawa, Junki Fujita, Shuhei Takise, Takahiro Ochiai, Yu Ueta, Masaki Yoshimatsu, Noboru Inoue, Hiroto Muroi, Shinji Morita and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Masanobu NakajimaDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan. mnakajim@dokkyomed.ac.jp.ORCID 0000-0003-4204-7184
Masatoshi NakagawaDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Junki FujitaDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Shuhei TakiseDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Takahiro OchiaiDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Yu UetaDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Masaki YoshimatsuDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Noboru InoueDepartment of Surgery, Dokkyo Medical University Nikko Medical Center, 145-1 Moritomo, Nikko, Tochigi, 321-1298, Japan.
Hiroto MuroiDepartment of Surgery, Dokkyo Medical University Nikko Medical Center, 145-1 Moritomo, Nikko, Tochigi, 321-1298, Japan.
Shinji MoritaDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Kazuyuki KojimaDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBarrett's mucosa in the remnant esophagus (BMRE) is often identified after gastric pull-up reconstruction after esophagectomy. This study aimed to determine the clinical characteristics of BMRE and the factors that affect the development of BMRE.

methodsThe characteristics of BMRE and factors affecting its occurrence were studied in patients with subtotal esophagectomy and gastric pull-up reconstruction who survived at least 3 years after esophageal cancer surgery and who were evaluated by endoscopy.

resultsA total of 187 eligible patients were identified, BMRE was found in 105 (56.1%) patients. The mean time from esophagectomy to confirmation of BMRE was 667.4 days. Ninety-four (89.5%) patients had ultra-short segment BMRE, nine (8.6%) had short segment BMRE, and one (1.0%) had long segment BMRE. Patients with BMRE were significantly younger than those without BMRE (p < 0.001). The incidence of gastro-esophageal reflux disease (GERD) and the frequency of severe GERD (Grade C and D) were significantly higher in the BMRE-positive group than in the BMRE-negative group (both p < 0.001). BMRE was less frequent in patients who were taking potassium-competitive acid blockers than in those who were not (p = 0.047). A logistic regression analysis showed that a younger age (≤ 67 years) (p = 0.002) and GERD (p < 0.001) were independent risk factors for BMRE.

conclusionsBMRE frequently occurs in patients with gastric pull-up reconstruction. The presence of GERD at a young age and more severe GERD increase the incidence of BMRE, and the administration of potassium-competitive acid blockers may decrease BMRE.

Indexed as

Barrett EsophagusEsophageal NeoplasmsEsophagectomyPostoperative ComplicationsAgedAnastomosis, SurgicalEsophageal MucosaEsophagoscopyEsophagusFemaleGastroesophageal RefluxHumansMaleMiddle AgedRetrospective StudiesRisk FactorsBarrett’s esophagusEsophagectomyGastro-esophageal reflux

Identifiers

PMID40931150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.