Evidence map›Paper›PMID 40931133›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026

Age-related risk factors and treatment outcomes in geriatric patients with spinal low-grade glioma: A nationwide analysis.

Joseph Rajasekaran, Taha Khalilullah, Xinlan Yang, Abdul Karim Ghaith, Shaan Bhandarkar, Meghana Bhimreddy, Richard Crawford, Nicholas Theodore, Daniel Lubelski

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Joseph RajasekaranDrexel University, Philadelphia, USA.
Taha KhalilullahJohns Hopkins University, Baltimore, USA.
Xinlan YangJohns Hopkins University, Baltimore, USA.
Abdul Karim GhaithJohns Hopkins University, Baltimore, USA. abdulkarimghaith@gmail.com.
Shaan BhandarkarJohns Hopkins University, Baltimore, USA.
Meghana BhimreddyJohns Hopkins University, Baltimore, USA.
Richard CrawfordUniformed Services University of the Health Sciences, Bethesda, USA.
Nicholas TheodoreJohns Hopkins University, Baltimore, USA.
Daniel LubelskiJohns Hopkins University, Baltimore, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpinal low-grade glioma (SLGG) is a rare and aggressive central nervous system malignancy affecting all age groups. Elderly patients were known to have distinct disease manifestations and prognosis from younger adults, nevertheless, little is known about age-related differences within the geriatric population. This study aims to evaluate treatment modalities and outcomes across geriatric age groups, investigate age-related risk factors, and optimize clinical interventions that reinforce the unique characteristics of geriatric patients.

methodsPatients aged ≥ 65 years with WHO grade 1 and 2 spinal gliomas diagnosed between 2004 and 2017 were identified from the National Cancer Database (NCDB). Patients were stratified into four geriatric age groups: 65–70, 71–75, 76–80, and > 80 years. Baseline demographics, clinical characteristics, treatment modalities (surgery and radiation) and outcomes were analyzed. Kaplan-Meier survival analysis assessed overall survival (OS), and a multivariate Cox proportional hazards regression model identified independent risk factors for mortality.

resultsA total of 119 geriatric SLGG patients were included: ages 65–70 (n = 51), 71–75 (n = 21), 76–80 (n = 32), and > 80 (n = 15). Demographic variables including sex, race, insurance status, and income quartile showed no significant differences across age groups (p > 0.05). However, Charlson-Deyo Comorbidity Classification (CDCC) scores differed significantly (p = 0.026), with a higher prevalence of scores ≥ 2 in the 76–80 age group. Five-year mortality rates varied significantly across age groups, with the highest observed in patients aged > 80 (93.3%) and the lowest in those aged 71–75 (42.9%, p = 0.017). Multivariate Cox regression identified age > 80 (HR = 2.96, 95% CI: 1.51–5.54, p = 0.002) and a CDCC score ≥ 2 (HR = 2.20, 95% CI: 1.19–4.06, p = 0.011) as independent predictors of increased mortality. Treatment modality and radiation dose did not significantly influence OS (p > 0.05).

conclusionsAge over 80 and increased comorbidity burden were independently associated with worse survival among geriatric SLGG patients, whereas surgery, radiation, and chemotherapy showed no differences in improving survival outcomes in this NCDB cohort.

Indexed as

GliomaSpinal NeoplasmsAgedAged, 80 and overAge FactorsFemaleHumansMaleRisk FactorsTreatment OutcomeGeriatricLow grade gliomaMortality risk prediction

Identifiers

PMID40931133

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.