Evidence map›Paper›PMID 40931125›Full record

ArticleNature reviews. Cancer2026

Are GLP-1 receptor agonists a 'magic bullet' for cancer?

James R Hebert, E Angela Murphy, Mary C Playdon, Liza Makowski, Anna R Ibele, Ciaran M Fairman, Lorne J Hofseth

Abstract read
In one paragraph

Article in Nature reviews. Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James R HebertCancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. jhebert@sc.edu.ORCID http://orcid.org/0000-0002-0677-2672
E Angela MurphyDepartment of Pathology, Microbiology & Immunology, School of Medicine, University of South Carolina, Columbia, SC, USA.
Mary C PlaydonDepartment of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Liza MakowskiDepartment of Medicine, Division of Hematology and Oncology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-5337-8037
Anna R IbeleDepartment of Surgery, University of Utah, Salt Lake City, UT, USA.
Ciaran M FairmanDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Lorne J HofsethDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.ORCID http://orcid.org/0000-0002-3200-452X

Funding

The Center for Clinical and Translational Research at the University of South Carolina (CLINTRUSC)P20GM155896 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI JAMES R HEBERT, FRANCIS G SPINALE · 2024 to 2026
$9.5M
Determining the contribution of microbial-derived metabolites to protective immunity in obesity-driven cancer risk.U01CA272541 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Liza Makowski-Hayes, Joseph F PIERRE · 2022 to 2026
$5.1M
Ceramides as novel drivers of metabolic dysfunction and colorectal cancerU01CA272529 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Mary Christine Playdon, SCOTT A SUMMERS · 2022 to 2026
$4.7M
A Transdisciplinary Approach to Investigating Metabolic Dysregulation in Obese Parent and Child Dyads and Risk of Colorectal Cancer - admin supplementU01CA272977 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI JAMES R HEBERT, Lorne J Hofseth · 2022 to 2026
$4.7M
Role of microbial-modulated bile acid receptor signaling in breast cancerR01CA253329 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Katherine Loree Cook, Liza Makowski-Hayes · 2020 to 2026
$3.0M
NCI NIH HHS R01 CA253329NCI NIH HHS U01 CA272529NCI NIH HHS U01 CA272541NCI NIH HHS U01 CA272977NIGMS NIH HHS P20 GM155896
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40931125
PMCPMC13291921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.