Evidence map›Paper›PMID 40931105›Full record

ArticleCellular & molecular immunology2025

Endothelial cell-ILC3 crosstalk via the ET-1/EDNRA axis promotes NKp46

Xinyao Li, Yimin Chen, Junyu He, Jian Tang, Chunling Chen, Liyun Meng, Yizhuang Lu, Xiaoming Lyu, Yuxiong Guo, Yumei He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinyao Li *Pediatric Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences); Department of Immunology, School of Basic Medical Sciences; Department of Clinical Laboratory, the Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
Yimin Chen *Department of Immunology, School of Basic Medical Sciences; Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles; Southern Medical University, Guangzhou, China.
Junyu He *Department of Immunology, School of Basic Medical Sciences; Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles; Southern Medical University, Guangzhou, China.
Jian Tang *Department of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Chunling ChenPediatric Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Liyun MengPediatric Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yizhuang LuDepartment of Immunology, School of Basic Medical Sciences; Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles; Southern Medical University, Guangzhou, China.
Xiaoming LyuDepartment of Clinical Laboratory, the Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China. xiaomlyu@smu.edu.cn.
Yuxiong GuoPediatric Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. guoyuxiong@gdph.org.cn.
Yumei HePediatric Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences); Department of Immunology, School of Basic Medical Sciences; Department of Clinical Laboratory, the Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China. hym0909@smu.edu.cn.ORCID 0000-0003-4745-3210

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82171706National Natural Science Foundation of China (National Science Foundation of China) 82471736
6 · The paper itself

Abstract

Communication between group 3 innate lymphoid cells (ILC3) and other immune cells, as well as intestinal epithelial cells, is pivotal in regulating intestinal inflammation. This study, for the first time, underscores the importance of crosstalk between intestinal endothelial cells (ECs) and ILC3. Our single-cell transcriptome analysis combined with protein expression detection revealed that ECs significantly increased the population of interleukin (IL)-22

Indexed as

Antigens, LyCell CommunicationEndothelial CellsEndothelin-1GlycolysisInflammationIntestinesLymphocytesNatural Cytotoxicity Triggering Receptor 1AnimalsColitisHumansHypoxia-Inducible Factor 1, alpha SubunitInterleukin-22InterleukinsMiceAntigens, LyEndothelin-1Hypoxia-Inducible Factor 1, alpha SubunitInterleukin-22InterleukinsNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouseProto-Oncogene Proteins c-aktCrosstalkEndothelial cellsET-1–EDNRA axisGlycolysisILC3

Identifiers

PMID40931105
PMCPMC12575790

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.