Evidence map›Paper›PMID 40931094›Full record

ArticleNPJ biofilms and microbiomes2025

ABO blood group antigens influence host-microbe interactions and risk of early spontaneous preterm birth.

Katherine E Mountain, David A MacIntyre, Yun S Lee, Virginia Tajadura-Ortega, Anne Dell, Stuart M Haslam, Gang Wu, Paola Grassi, Ten Feizi, Yan Liu and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Katherine E MountainImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
David A MacIntyreImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Yun S LeeImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Virginia Tajadura-OrtegaMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Anne DellMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Stuart M HaslamMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Gang WuMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Paola GrassiMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Ten FeiziMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Yan LiuMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Wengang ChaiMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Julian R MarchesiMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Lauren A RobertsMarch of Dimes Prematurity Research Center at Imperial College London, London, UK.
Denise ChanImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Belen Gimeno-MolinaImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Richard G BrownImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Holly V LewisImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Alice K C HydeImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
James Pasint-MagyarImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Anna GreenImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Anna L DavidElizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
Jane E NormanUniversity of Nottingham, Nottingham, UK.
Sarah J StockUniversity of Edinburgh, Edinburgh, UK.
Samit KunduImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Sherrianne NgImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Ben GlampsonDigital Collaboration Space, Imperial Clinical Analytics, Research & Evaluation (iCARE) Secure Data Environment, Imperial College London & Imperial College Healthcare NHS Trust, London, UK.
Erik MayerDigital Collaboration Space, Imperial Clinical Analytics, Research & Evaluation (iCARE) Secure Data Environment, Imperial College London & Imperial College Healthcare NHS Trust, London, UK.
T G TeohImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Vasso TerzidouImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Phillip R BennettImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Lynne SykesImperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. l.sykes@imperial.ac.uk.

Funding

Wellcome Trust
6 · The paper itself

Abstract

The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic (n = 596) and immune profiling (n = 314) data, we show that the B blood group phenotype associates with increased risk of sPTB and adverse vaginal microbiota composition. The O blood group associates with sPTB in women who have a combination of a previous history of sPTB, an adverse vaginal microbial composition and pro-inflammatory cervicovaginal milieu. In contrast, women of blood group A have a higher prevalence of vaginal Lactobacillus crispatus, a lower risk of sPTB, with sPTB cases showing no association with vaginal microbiota composition or inflammation. We found that cervicovaginal fluid contains ABH(O) glycans and shows variable binding to key vaginal bacteria. This indicates that cervicovaginal ABH(O) glycans influence microbiota-host interactions implicated in sPTB risk, suggesting a novel target for sPTB prediction and prevention.

Indexed as

ABO Blood-Group SystemHost Microbial InteractionsPremature BirthAdultBacteriaFemaleHumansMicrobiotaPolysaccharidesPregnancyRisk FactorsVaginaABO Blood-Group SystemPolysaccharides

Identifiers

PMID40931094
PMCPMC12423329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.