ArticleNature2025
Functional synapses between neurons and small cell lung cancer.
Erratum issuedAbstract read
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Sensory innervation shapes cancer immunotherapy efficacy and adverse events.Journal for immunotherapy of cancer · 2026Review
- Role of neuron-specific SWI/SNF complex subunit BAF53B: from neuron to small cell lung carcinoma.Human cell · 2026Article
- Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies.Cancer science · 2026Review
- Cancer Neuroscience: From Local Neuro-Immune Microenvironments to Systemic Brain-Body Circuitry.MedComm · 2026Review
- The neuronal network of small cell lung cancer: a narrative review of the role of the nervous system in the pathogenesis and progression.Translational lung cancer research · 2026Review
- Gastric cancer in the Era of neural regulation.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Neural regulation of cancer: from microenvironmental hijacking to systemic circuit co-option.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship.Genes & development · 2026Review
- Neural regulation of tumor immunity: emerging opportunities to enhance cancer immunotherapy.Experimental & molecular medicine · 2026Review
- Targeting Wild-type NTRK in NTRK Fusion-Negative Lung Cancer Decreases Brain Metastases.Cancer research communications · 2026Article
- Neural regulation of cancer: from synaptic integration to neuro-immune regulation.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro-Ecological Perspective.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Transsynaptic tracing techniques to interrogate neuronal connectivity of glioblastomas.Nature protocols · 2026Review
- Molecular mechanisms and therapeutic targets in lung cancer-nerve crosstalk.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Pan-Cancer Prognostic Analysis of NMDAR Genes Discovered Therapeutic Implications of Neuronal-Cancer Crosstalk Mediator GRIN2A for Small Cell Lung Cancer.Biomedicines · 2026Article
- Adenosine Signaling in Primary and Metastatic Brain Tumors: Immune Suppression, Tumor Progression, and Therapeutic Opportunities.Molecular neurobiology · 2026Review
- Article
- Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Cancer Neoaxonogenesis: Mechanisms and Factors Involved in the Recruitment of Peripheral Nerves by Cancer Tissue.International journal of molecular sciences · 2026Review
- Review
Corrections and comments
- Erratum issued
Authors and funding
75 authors.
Vignesh Sakthivelu *Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0000-1652-0850
Anna Schmitt *Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Franka Odenthal *Institute of Biochemistry, University of Cologne, Cologne, Germany.ORCID 0000-0003-4138-121X
Kristiano Ndoci *Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID 0000-0002-9896-8196
Marian Touet *Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0004-7875-1880
Ali H Shaib *Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany.
Abdulla Chihab *Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID 0009-0002-1237-0087
Gulzar A WaniCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID 0000-0003-2380-5816
Pascal NieperDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Griffin G HartmannDepartment of Pediatrics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9213-8995
Isabel PintelonLaboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Ilmars KisisDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-6207-3991
Maike BoeckerDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0008-0595-8599
Naja M EckertDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0007-2888-0280
Manoela Iannicelli CaiaffaDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0007-0704-0397
Olta IbruliDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Julia WeberInstitute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.
Roman MareschInstitute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.ORCID 0000-0003-3393-8882
Christina M BebberDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-7841-7493
Ali ChitsazDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Anna LützDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0000-2891-7038
Mira Kim Alves CarpinteiroDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Kaylee M MorrisInstitute of Biochemistry, University of Cologne, Cologne, Germany.
Camilla A FranchinoInstitute of Biochemistry, University of Cologne, Cologne, Germany.
Jonas BenzCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Laura Pérez-RevueltaCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Jorge A Soriano-CamposCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Maxim A HuetzenDepartment I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0008-2217-813X
Jonas GoergensDepartment I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Milica JevticCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Hannah M Jahn-KelleterCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Hans ZempelCenter for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-7510-3077
Aleksandra PlaczekCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Alexandru A HennrichVirology, Max von Pettenkofer Institute, Faculty of Medicine and Gene Center, Ludwig Maximilians University, Munich, Germany.ORCID 0000-0002-3233-6145
Karl-Klaus ConzelmannVirology, Max von Pettenkofer Institute, Faculty of Medicine and Gene Center, Ludwig Maximilians University, Munich, Germany.ORCID 0000-0002-8614-3656
Hannah L TumbrinkDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Pascal HunoldDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-7087-5908
Joerg IsenseeTranslational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-3390-0051
Lisa WerrDepartment of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany.ORCID 0000-0002-3697-4136
Felix GaedkeCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID 0000-0002-7744-4940
Astrid SchaussCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID 0000-0002-6658-2192
Marielle MinèreCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID 0000-0001-7889-9771
Marie MüllerCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Henning FenselauCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID 0000-0001-7136-9751
Yin LiuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-2377-2703
Alena HeimsoethDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Gülce S Gülcüler BaltaDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-3626-007X
Henning WalczakCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Christian FrezzaInstitute for Metabolomics in Ageing, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.ORCID 0000-0002-3293-7397
Ron D JachimowiczDepartment I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-9522-7061
Julie GeorgeDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-4272-3683
Marcel SchmielInstitute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Johannes BrägelmannDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-1306-2169
Tim HuchoTranslational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-4147-9308
Silvia von KarstedtDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-7816-5919
Martin PeiferDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-5243-5503
Alessandro AnnibaldiCenter for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Robert Hänsel-HertschDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-2835-4471
Thorsten PersigehlInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Holger GrüllInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Martin L SosDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-2868-100X
Guido ReifenbergerInstitute of Neuropathology, Medical Faculty, Heinrich Heine University and University Hospital Düsseldorf, Düsseldorf, Germany.
Matthias FischerCenter for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0003-1363-1242
Dirk AdriaensenLaboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Reinhard BüttnerInstitute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-8806-4786
Julien SageDepartment of Pediatrics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8928-9968
Inge BrounsLaboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Roland RadInstitute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.ORCID 0000-0002-6849-9659
Roman K ThomasDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-9132-4876
Max AnstötzInstitute of Anatomy II, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. max.anstoetz@hhu.de.ORCID 0000-0003-3071-5835
Silvio O RizzoliDepartment of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany. srizzol@gwdg.de.ORCID 0000-0002-1667-7839
Matteo BergamiCologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. matteo.bergami@uk-koeln.de.ORCID 0000-0001-5525-5025
Elisa MotoriInstitute of Biochemistry, University of Cologne, Cologne, Germany. elisa.motori@uni-koeln.de.ORCID 0000-0001-5997-6866
Hans Christian ReinhardtDepartment of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany. christian.reinhardt@uk-essen.de.ORCID 0000-0001-5706-9349
Filippo BeleggiaDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. filippo.beleggia@uk-koeln.de.ORCID 0000-0003-0234-7094
Funding
Investigating molecular and cellular mechanisms of SCLC development to identify novel therapeutic strategiesR35CA231997 · NCI · STANFORD UNIVERSITY · PI SAGE, JULIEN · 2019 to 2025
$6.2MNCI NIH HHS R35 CA231997Wellcome Trust 214342
Abstract
Small cell lung cancer (SCLC) is a highly aggressive type of lung cancer, characterized by rapid proliferation, early metastatic spread, frequent early relapse and a high mortality rate
Indexed as
Lung NeoplasmsNeuronsSmall Cell Lung CarcinomaSynapsesAnimalsCell Line, TumorCell ProliferationCoculture TechniquesDisease Models, AnimalFemaleGlutamic AcidHumansMaleMiceMutagenesis, InsertionalOptogeneticsGlutamic AcidReceptors, GABA-AReceptors, N-Methyl-D-Aspartate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.