ArticleNature2025
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
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Who cites it
45 citing papers in PubMed.
- The Role of the Nervous System in Lung Disease.Current neurology and neuroscience reports · 2026Review
- Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies.Cancer science · 2026Review
- Cancer Neuroscience: From Local Neuro-Immune Microenvironments to Systemic Brain-Body Circuitry.MedComm · 2026Review
- The neuronal network of small cell lung cancer: a narrative review of the role of the nervous system in the pathogenesis and progression.Translational lung cancer research · 2026Review
- Gastric cancer in the Era of neural regulation.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Neural regulation of cancer: from microenvironmental hijacking to systemic circuit co-option.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Neuroscience in cancer care: ethical, legal, and societal challenges.Molecular psychiatry · 2026Article
- Neural regulation in lung cancer: from mechanisms to new therapeutic perspectives.Clinical and experimental medicine · 2026Review
- Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship.Genes & development · 2026Review
- Neural regulation of tumor immunity: emerging opportunities to enhance cancer immunotherapy.Experimental & molecular medicine · 2026Review
- Targeting Wild-type NTRK in NTRK Fusion-Negative Lung Cancer Decreases Brain Metastases.Cancer research communications · 2026Article
- Neural regulation of cancer: from synaptic integration to neuro-immune regulation.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Wired for immunity: neuroimmune control of the lung by sensory neurons.Nature reviews. Neuroscience · 2026Review
- Neuron-tumor crosstalk in cancer: molecular mechanisms and translational advances.Molecular cancer · 2026Review
- Transsynaptic tracing techniques to interrogate neuronal connectivity of glioblastomas.Nature protocols · 2026Review
- Molecular mechanisms and therapeutic targets in lung cancer-nerve crosstalk.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases.Nature communications · 2026Article
- Pan-Cancer Prognostic Analysis of NMDAR Genes Discovered Therapeutic Implications of Neuronal-Cancer Crosstalk Mediator GRIN2A for Small Cell Lung Cancer.Biomedicines · 2026Article
- Article
- Cancer Neoaxonogenesis: Mechanisms and Factors Involved in the Recruitment of Peripheral Nerves by Cancer Tissue.International journal of molecular sciences · 2026Review
Corrections and comments
- Update of
Authors and funding
29 authors.
Solomiia Savchuk *Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Kaylee M Gentry *Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Wengang WangDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4659-6909
Elana CarletonDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Carlos A O Biagi-JuniorDepartment of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0700-3135
Karan LuthriaDepartment of Medicine, Division of Hematology/Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4392-9675
Belgin YalçınDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9689-9062
Lijun NiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Hannah C FarnsworthDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Rachel A DavisDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Richard DrexlerDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Johannes C MelmsDepartment of Medicine, Division of Hematology/Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5410-6586
Yin LiuDepartment of Biochemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2377-2703
Lehi Acosta-AlvarezDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2890-4947
Griffin G HartmannDepartments of Pediatrics and Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9213-8995
Elisa C PavarinoDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Jenna LaBelleDepartment of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Pamelyn J WooDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Angus M TolandDepartment of Pathology, Stanford University, Stanford, CA, USA.
Fangfei QuDepartments of Pediatrics and Genetics, Stanford University, Stanford, CA, USA.
Yoon Seok KimDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Mariella G FilbinDepartment of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Mark A KrasnowDepartment of Biochemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1976-5471
Keith L LigonDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7733-600X
Benjamin IzarDepartment of Medicine, Division of Hematology/Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2379-6702
Julien SageDepartments of Pediatrics and Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8928-9968
Bernardo L SabatiniDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0095-9177
Michelle MonjeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.ORCID http://orcid.org/0000-0002-3547-237X
Humsa S VenkateshDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA. hvenkatesh@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-1194-3015
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MTargeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Tracy T Batchelor · 2013 to 2026
$33.5MStudying the evolution of drug resistance in prostate cancer at the single cell levelU54CA274506 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DIANA MURRAY · 2023 to 2026
$9.1MTargeting the neuronal microenvironment in glioblastomaU19CA264504 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Michelle Monje-Deisseroth · 2021 to 2026
$6.4MInvestigating molecular and cellular mechanisms of SCLC development to identify novel therapeutic strategiesR35CA231997 · NCI · STANFORD UNIVERSITY · PI SAGE, JULIEN · 2019 to 2025
$6.2MGlioma Circuitry: Bridging Systems Neuroscience and CancerDP1NS111132 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2018 to 2022
$5.7MAction and interaction of ionotropic and metabotropic neurotransmissionR37NS046579 · NINDS · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2018 to 2024
$4.6MNeuronal Regulation of Low-Grade GliomagenesisR01CA258384 · NCI · STANFORD UNIVERSITY · PI David H Gutmann, Michelle Monje-Deisseroth · 2022 to 2026
$3.1MMulti-cellular interactions defining the human brain metastatic nicheR01CA280414 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Benjamin Izar, Ashley Marie Laughney · 2023 to 2026
$2.8MMechanisms of liver metastasis and associated resistance to immunotherapyR37CA258829 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Benjamin Izar · 2021 to 2026
$2.6MUnraveling Neural Circuitry in Peripheral Cancer Pathogenesis: From Local Innervation to Systemic InfluencesDP2CA290968 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Humsa Venkatesh · 2023 to 2026
$2.5MAction and Interaction of Neurotransmitters and NeuromodulatorsR35NS137336 · NINDS · HARVARD MEDICAL SCHOOL · PI Bernardo L Sabatini · 2024 to 2026
$2.1MNCI NIH HHS DP2 CA290968NCI NIH HHS P30 CA013696NCI NIH HHS P50 CA165962NCI NIH HHS R00 CA252001NCI NIH HHS R01 CA258384NCI NIH HHS R01 CA266446NCI NIH HHS R01 CA280414NCI NIH HHS R35 CA231997NCI NIH HHS R37 CA258829NCI NIH HHS U19 CA264504NCI NIH HHS U54 CA274506NINDS NIH HHS DP1 NS111132NINDS NIH HHS R01 NS092597NINDS NIH HHS R35 NS137336NINDS NIH HHS R37 NS046579
Abstract
Neural activity is increasingly recognized as a crucial regulator of cancer growth. In the brain, neuronal activity robustly influences glioma growth through paracrine mechanisms
Indexed as
Lung NeoplasmsNeuronsSmall Cell Lung CarcinomaAnimalsBrain NeoplasmsCell Line, TumorCell ProliferationDisease ProgressionFemalegamma-Aminobutyric AcidGlutamic AcidHumansLungMaleMiceParacrine Communicationgamma-Aminobutyric AcidGlutamic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.