ArticleNature2025
Structure and mechanism of the mitochondrial calcium transporter NCLX.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- How mitochondrial heterogeneity fuels a dynamic organelle ecosystem.Communications biology · 2026Review
- Calcium dysregulation in neurovascular function in Alzheimer's disease: mechanisms, therapeutic targets.GeroScience · 2026Review
- Structures of the sodium-coupled phosphate importer SLC34A2 reveal a distinct architecture and gating mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mitochondrial Toxicology of Heavy Metals and Pesticides: Transport Systems, Mitochondrial Dysfunction and Permeability Transition.International journal of molecular sciences · 2026Review
- Molecular mechanisms of mitochondrial CaNature communications · 2026Article
- The role of mitochondrial Na⁺/Ca²⁺ exchanger in brain cell aging.Journal of bioenergetics and biomembranes · 2026Review
- Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.The EMBO journal · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Structural basis of metalloid transport by the arsenite efflux pump ArsB.Nature communications · 2026Article
- The pivotal role of mitochondria in the pathogenesis and treatment of liver failure: a comprehensive review.Molecular and cellular biochemistry · 2026Review
- From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family.Protein science : a publication of the Protein Society · 2026Review
- Mitochondrial Calcium Signaling in Hepatocyte Health and Disease.Cold Spring Harbor perspectives in biology · 2026Review
- Mitochondrial Calcium Dysregulation and Targeted Therapies in Heart Failure.Reviews in cardiovascular medicine · 2026Review
- Molecular mechanisms of mitochondrial CabioRxiv : the preprint server for biology · 2026Article
- Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish.Communications biology · 2026Article
- Mitochondrial CaFrontiers in cell and developmental biology · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Minrui Fan *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Chen-Wei Tsai *Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. nyc3zs@virginia.edu.ORCID 0009-0000-2469-8966
Jinru Zhang *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Jianxiu Zhang *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-1864-7510
Aswini R Krishnan *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0764-5111
Tsung-Yun LiuDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Yu-Lun HuangDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Deniz AydinDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-2758-2480
Siyuan DuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5215-0535
Briana L SobecksDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Madison X RodriguezDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Andrew H ReiterDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1406-4913
Carolyn R BertozziDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4482-2754
Ron O DrorDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6418-2793
Ming-Feng TsaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. vmf6uw@virginia.edu.ORCID 0000-0003-4277-1885
Liang FengDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. liangf@stanford.edu.ORCID 0000-0001-6171-2050
Funding
The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8MTargeting the Cancer GlycocalyxR01CA227942 · NCI · STANFORD UNIVERSITY · PI Carolyn Bertozzi · 2019 to 2026
$3.6MMolecular mechanisms of mitochondrial membrane transport systems in cellular energeticsR35GM153424 · NIGMS · STANFORD UNIVERSITY · PI Liang Feng · 2024 to 2026
$2.5MMolecular mechanisms of the mitochondrial calcium transport systemR35GM151958 · NIGMS · UNIVERSITY OF VIRGINIA · PI Ming-Feng Tsai · 2024 to 2026
$1.6MMolecular Physiology of Mitochondrial Calcium TransportersR01GM144485 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI TSAI, MING-FENG · 2021 to 2023
$968kNCI NIH HHS R01 CA227942NIGMS NIH HHS R01 GM144485NIGMS NIH HHS R35 GM151958NIGMS NIH HHS R35 GM153424NIGMS NIH HHS U24 GM129541
Abstract
As a key mitochondrial Ca
Indexed as
Mitochondrial Membrane Transport ProteinsSodium-Calcium ExchangerAnimalsCalciumCalcium SignalingCryoelectron MicroscopyHumansMitochondriaModels, MolecularProtein ConformationRatsCalciumMitochondrial Membrane Transport ProteinsSlc8b1 protein, ratSodium-Calcium Exchanger
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.