ArticleNature2025
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dietary choline intake and incident dementia in middle-aged and older adults: a prospective cohort study and dose-response meta-analysis.Nutrition journal · 2026Pooled it
- Single-Cell Transcriptomic Profiling Identifies B Cell-Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Lysine-specific demethylase 3A (KDM3A) protects against ovarian dysfunction in premature ovarian insufficiency by transcriptional activation of ATP-binding cassette sub-family A member 7 (ABCA7)-mediated mitochondrial homeostasis.Molecular biomedicine · 2026Article
- APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.Nature communications · 2026Article
- Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine and reduced Alzheimer's disease risk.Research square · 2026Article
- Article
- From the brain cell atlas to precision neurology: a review of the application of AI-driven multi-omics in brain science.GigaScience · 2026Review
- Alzheimer's disease in theFree neuropathology · 2026Article
- Article
- Effect of choline supplementation in presymptomaticAlzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Djuna von MaydellPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-6085-0491
Shannon E WrightPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ping-Chieh PaoPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-6788-7185
Colin StaabPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Oisín KingPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Andrea SpitaleriDepartment of Medical Biotechnologies and Translational Medicine, University of Milano, Milan, Italy.ORCID 0000-0003-3012-3557
Julia Maeve BonnerPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Liwang LiuPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Chung Jong YuPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ching-Chi ChiuPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-1827-8049
Daniel LeiblePicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0006-5491-6673
Aine Ni ScannailPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Mingpei LiPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Carles A BoixMIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.ORCID 0000-0001-9212-856X
Hansruedi MathysPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-0186-2115
Guillaume LeclercMIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.
Gloria Suella MenchacaPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Gwyneth WelchPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Agnese GraziosiPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-4992-7902
Noelle LearyPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
George SamaanPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Manolis KellisMIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.ORCID 0000-0001-7113-9630
Li-Huei TsaiPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.ORCID 0000-0003-1262-0592
Funding
The effects of Alzheimer's disease risk genes on metabolism and signaling across cell typesRF1AG075901 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FRAENKEL, ERNEST, TSAI, LI-HUEI · 2022 to 2025
$6.5MDemystifying Microglia in Aging and Alzheimer's DiseaseRF1AG054321 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DE JAGER, PHILIP L, LEVIN, JOSHUA ZVI · 2016 to 2016
$4.0MCell type specific epigenetic analysis to understand complex mechanisms underlying Alzheimer's disease phenotypesRF1AG054012 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS, TSAI, LI-HUEI · 2016 to 2016
$3.9MDissection of endosomal trafficking mechanisms in Alzheimer's DiseaseRF1AG062377 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2018 to 2018
$3.6MInvestigating cell-type specific convergence of APOE and ABCA7 lipid dysregulation in Alzheimer’s diseaseR56AG081376 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS, TSAI, LI-HUEI · 2023 to 2023
$754kNIA NIH HHS R56 AG081376NIA NIH HHS RF1 AG054012NIA NIH HHS RF1 AG054321NIA NIH HHS RF1 AG062377NIA NIH HHS RF1 AG075901
Abstract
Loss-of-function variants in the lipid transporter ABCA7 substantially increase the risk of Alzheimer's disease
Indexed as
ATP-Binding Cassette TransportersMitochondriaNeuronsPhosphatidylcholinesAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainFemaleHumansInduced Pluripotent Stem CellsLipid MetabolismMaleMolecular Dynamics SimulationOxidative StressABCA7 protein, humanAmyloid beta-PeptidesATP-Binding Cassette TransportersPhosphatidylcholines
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.